Engineered nanomaterials for their applications in theragnostics

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 66; pp. 20 - 28
• Main Authors: Hwang, Jangsun, Lee, Dohyun, Seo, Youngmin, Son, Jaewoo, Jo, Yeonho, Lee, Kyungwoo, Park, Chanhwi, Choi, Jonghoon
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.10.2018; 한국공업화학회
• Subjects: Carbon nanotube (CNT); Gold nanoparticles (GNPs); Immunotherapy; Iron oxide nanoparticles (IONPs); Silicon nanoparticles (SiNPs); 화학공학; Iron oxide nanoparticles (IONPs); Carbon nanotube (CNT); Gold nanoparticles (GNPs); Immunotherapy; Silicon nanoparticles (SiNPs)
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2018.05.022

Summary of several nanomaterials were reported for their preparation and characterization. Recent applications of nanomaterials for immunological studies and the highlight of major challenges and promises were discussed in employing them to the immunological applications. [Display omitted] Owing to their abundant unique properties and ready compatibility with healthcare and therapeutic technology, nanoparticles are becoming one of the most desirable materials in the biomedical industry. Particularly, novel nanoparticles possess distinctive photoluminescence, biocompatibility, antibacterial effect, surface plasmon resonance, and immunogenicity. In this review, we describe the general synthesis, physical properties, cellular activity, and biological applications of popular nanoparticles/nanomaterials (i.e., silicon, gold, iron oxide, and carbon nanotubes), while focusing on the immunology encompassing these nanoparticles and their potential applications in the fields of nanotherapy. We further highlight major challenges and promises in this area and review the uses of nanoparticles in current technologies, such as nanoparticle-mediated cellular immunology and cytotoxicity in therapeutic applications.