Comparison of Nocturnal Cough Analysis in Healthy Subjects and in Patients with Cystic Fibrosis and Primary Ciliary Dyskinesia: A Prospective Observational Study

• Published in: Respiration Vol. 97; no. 1; pp. 60 - 69
• Main Authors: Radine, Andrea, Werner, Claudius, Raidt, Johanna, Dougherty, Gerard W., Kerschke, Laura, Omran, Heymut, Grosse-Onnebrink, Joerg
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2019
• Subjects: Adolescent; Adult; Child; Ciliary Motility Disorders - complications; Ciliary Motility Disorders - diagnosis; Circadian Rhythm - physiology; Clinical Investigations; Cough - diagnosis; Cough - etiology; Cystic Fibrosis - complications; Cystic Fibrosis - diagnosis; Female; Follow-Up Studies; Forced Expiratory Volume - physiology; Healthy Volunteers; Humans; Male; Middle Aged; Monitoring, Physiologic - methods; Prospective Studies; Respiratory Function Tests; Severity of Illness Index; Young Adult; Cystic fibrosis; Cough frequency; Primary ciliary dyskinesia; Objective cough count

Background: Cough is a key symptom in patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). Objective: The study objectives were to test whether cough is related to parameters reflecting their disease severity and whether CF and PCD differ in cough frequency. Methods: In this pros...