Redox- and pH-responsive fluorescent carbon nanoparticles-MnO2-based FRET system for tumor-targeted drug delivery in vivo and in vitro
[Display omitted] •The cancer targeted biosensor showed with redox/pH controllable PTX delivery system guided fluorescent on/off behavior.•The system generates fluorescent off-on system in response to high intracellular GSH concentration and drug release.•The MnO2/PTX-loaded C-FNP can effectively re...
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| Published in | Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 63; pp. 208 - 219 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
25.07.2018
한국공업화학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-086X 1876-794X |
| DOI | 10.1016/j.jiec.2018.02.017 |
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| Abstract | [Display omitted]
•The cancer targeted biosensor showed with redox/pH controllable PTX delivery system guided fluorescent on/off behavior.•The system generates fluorescent off-on system in response to high intracellular GSH concentration and drug release.•The MnO2/PTX-loaded C-FNP can effectively reduce the side effects In vitro and In vivo of cancer cell.•The formulation showed an selective cellular uptake of malignant KB cells suggesting a potential for targeting.
The carbonized boronic acid-conjugated fluorescent carbon nanoparticles (FNPs) were crosslinked with carbonized dopamine-conjugated hyaluronic acid (HA) via the diol boronic acid-linked catechol groups [C-FNP] as extracellular targeting ligands and pH responsiveness. Into that C-FNP, the redox-responsive MnO2 nanosheets were loaded to demonstrate quenching effect, which recovered after glutathione (GSH) treatment. The MnO2-loaded C-FNP showed excellent stability and tumor-targeting ability guided to the localized tumor using “on–off” fluorescent switch. Furthermore, paclitaxel (PTX) inside the MnO2-loaded C-FNP performed in vitro and in vivo bioimaging and chemotherapeutic activities analyzed towards cancer and non-cancerous cells. |
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| AbstractList | [Display omitted]
•The cancer targeted biosensor showed with redox/pH controllable PTX delivery system guided fluorescent on/off behavior.•The system generates fluorescent off-on system in response to high intracellular GSH concentration and drug release.•The MnO2/PTX-loaded C-FNP can effectively reduce the side effects In vitro and In vivo of cancer cell.•The formulation showed an selective cellular uptake of malignant KB cells suggesting a potential for targeting.
The carbonized boronic acid-conjugated fluorescent carbon nanoparticles (FNPs) were crosslinked with carbonized dopamine-conjugated hyaluronic acid (HA) via the diol boronic acid-linked catechol groups [C-FNP] as extracellular targeting ligands and pH responsiveness. Into that C-FNP, the redox-responsive MnO2 nanosheets were loaded to demonstrate quenching effect, which recovered after glutathione (GSH) treatment. The MnO2-loaded C-FNP showed excellent stability and tumor-targeting ability guided to the localized tumor using “on–off” fluorescent switch. Furthermore, paclitaxel (PTX) inside the MnO2-loaded C-FNP performed in vitro and in vivo bioimaging and chemotherapeutic activities analyzed towards cancer and non-cancerous cells. The carbonized boronic acid-conjugated fluorescent carbon nanoparticles (FNPs) were crosslinked with carbonized dopamine-conjugated hyaluronic acid (HA) via the diol boronic acid-linked catechol groups [C-FNP] as extracellular targeting ligands and pH responsiveness. Into that C-FNP, the redox-responsive MnO2 nanosheets were loaded to demonstrate quenching effect, which recovered after glutathione (GSH) treatment. The MnO2-loaded C-FNP showed excellent stability and tumor-targeting ability guided to the localized tumor using “on–off” fluorescent switch. Furthermore, paclitaxel (PTX) inside the MnO2-loaded C-FNP performed in vitro and in vivo bioimaging and chemotherapeutic activities analyzed towards cancer and non-cancerous cells. KCI Citation Count: 52 |
| Author | Mazrad, Zihnil Adha Islamy Choi, Cheong A Jeong, Ji Hoon Park, Sung Young In, Insik Lee, Jung Eun |
| Author_xml | – sequence: 1 givenname: Cheong A surname: Choi fullname: Choi, Cheong A organization: Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea – sequence: 2 givenname: Jung Eun surname: Lee fullname: Lee, Jung Eun organization: School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon-si, Gyeonggi-do 440-746, Republic of Korea – sequence: 3 givenname: Zihnil Adha Islamy surname: Mazrad fullname: Mazrad, Zihnil Adha Islamy organization: Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea – sequence: 4 givenname: Insik orcidid: 0000-0001-7852-1162 surname: In fullname: In, Insik organization: Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea – sequence: 5 givenname: Ji Hoon surname: Jeong fullname: Jeong, Ji Hoon email: jhjeong@skku.edu organization: School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon-si, Gyeonggi-do 440-746, Republic of Korea – sequence: 6 givenname: Sung Young orcidid: 0000-0002-0358-6946 surname: Park fullname: Park, Sung Young email: parkchem@ut.ac.kr organization: Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea |
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•The cancer targeted biosensor showed with redox/pH controllable PTX delivery system guided fluorescent on/off behavior.•The system generates... The carbonized boronic acid-conjugated fluorescent carbon nanoparticles (FNPs) were crosslinked with carbonized dopamine-conjugated hyaluronic acid (HA) via... |
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| SubjectTerms | Fluorescent carbon nanoparticle MnO2 sheet pH sensitive Redox responsive Targeted delivery 화학공학 |
| Title | Redox- and pH-responsive fluorescent carbon nanoparticles-MnO2-based FRET system for tumor-targeted drug delivery in vivo and in vitro |
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