Effect of Ramadan fasting on renal function in patients with type 2 diabetes
To evaluate the effect of Ramadan fasting on kidney functions in patients with type 2 DM. We recruited 90 subjects with type 2 DM intending to fast Ramadan; classified into 30 with albuminuria and renal impairment (group I), 30 with albuminuria and normal kidney functions (group II) and 30 without a...
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Published in | Diabetes research and clinical practice Vol. 153; pp. 176 - 183 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier B.V
01.07.2019
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Subjects | |
Online Access | Get full text |
ISSN | 0168-8227 1872-8227 1872-8227 |
DOI | 10.1016/j.diabres.2019.05.036 |
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Abstract | To evaluate the effect of Ramadan fasting on kidney functions in patients with type 2 DM.
We recruited 90 subjects with type 2 DM intending to fast Ramadan; classified into 30 with albuminuria and renal impairment (group I), 30 with albuminuria and normal kidney functions (group II) and 30 without albuminuria and normal kidney functions (group III). Two weeks before and after Ramadan, fasting plasma glucose, 2 h plasma glucose, hemoglobin A1c, fructosamine, serum creatinine, BUN, eGFR and albumin/ creatinine ratio were measured.
On comparing data before and after Ramadan, significant reduction in HbA1c was found in all groups. As regards kidney function parameters, no significant difference was found in group I but a significant decline in these parameters was found in groups II and III; serum creatinine, eGFR, urinary albumin/ creatinine ratio (p <0.001). Only Group I showed significant hypoglycemic events and need for dose reduction.
Ramadan fasting improved glycemic control in patients with type 2 DM with no decline in kidney functions in renally impaired group, only a decline in albuminuric and healthy groups within the normal range. Patients should be adviced regarding adequate hydration and dietary modification during Pre-Ramadan health care education. |
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AbstractList | To evaluate the effect of Ramadan fasting on kidney functions in patients with type 2 DM.
We recruited 90 subjects with type 2 DM intending to fast Ramadan; classified into 30 with albuminuria and renal impairment (group I), 30 with albuminuria and normal kidney functions (group II) and 30 without albuminuria and normal kidney functions (group III). Two weeks before and after Ramadan, fasting plasma glucose, 2 h plasma glucose, hemoglobin A1c, fructosamine, serum creatinine, BUN, eGFR and albumin/ creatinine ratio were measured.
On comparing data before and after Ramadan, significant reduction in HbA1c was found in all groups. As regards kidney function parameters, no significant difference was found in group I but a significant decline in these parameters was found in groups II and III; serum creatinine, eGFR, urinary albumin/ creatinine ratio (p <0.001). Only Group I showed significant hypoglycemic events and need for dose reduction.
Ramadan fasting improved glycemic control in patients with type 2 DM with no decline in kidney functions in renally impaired group, only a decline in albuminuric and healthy groups within the normal range. Patients should be adviced regarding adequate hydration and dietary modification during Pre-Ramadan health care education. To evaluate the effect of Ramadan fasting on kidney functions in patients with type 2 DM.AIMTo evaluate the effect of Ramadan fasting on kidney functions in patients with type 2 DM.We recruited 90 subjects with type 2 DM intending to fast Ramadan; classified into 30 with albuminuria and renal impairment (group I), 30 with albuminuria and normal kidney functions (group II) and 30 without albuminuria and normal kidney functions (group III). Two weeks before and after Ramadan, fasting plasma glucose, 2 h plasma glucose, hemoglobin A1c, fructosamine, serum creatinine, BUN, eGFR and albumin/ creatinine ratio were measured.METHODSWe recruited 90 subjects with type 2 DM intending to fast Ramadan; classified into 30 with albuminuria and renal impairment (group I), 30 with albuminuria and normal kidney functions (group II) and 30 without albuminuria and normal kidney functions (group III). Two weeks before and after Ramadan, fasting plasma glucose, 2 h plasma glucose, hemoglobin A1c, fructosamine, serum creatinine, BUN, eGFR and albumin/ creatinine ratio were measured.On comparing data before and after Ramadan, significant reduction in HbA1c was found in all groups. As regards kidney function parameters, no significant difference was found in group I but a significant decline in these parameters was found in groups II and III; serum creatinine, eGFR, urinary albumin/ creatinine ratio (p <0.001). Only Group I showed significant hypoglycemic events and need for dose reduction.RESULTSOn comparing data before and after Ramadan, significant reduction in HbA1c was found in all groups. As regards kidney function parameters, no significant difference was found in group I but a significant decline in these parameters was found in groups II and III; serum creatinine, eGFR, urinary albumin/ creatinine ratio (p <0.001). Only Group I showed significant hypoglycemic events and need for dose reduction.Ramadan fasting improved glycemic control in patients with type 2 DM with no decline in kidney functions in renally impaired group, only a decline in albuminuric and healthy groups within the normal range. Patients should be adviced regarding adequate hydration and dietary modification during Pre-Ramadan health care education.CONCLUSIONRamadan fasting improved glycemic control in patients with type 2 DM with no decline in kidney functions in renally impaired group, only a decline in albuminuric and healthy groups within the normal range. Patients should be adviced regarding adequate hydration and dietary modification during Pre-Ramadan health care education. |
Author | Abdullah, A. Bekhet, M. Samy, M. Abushady, M.M. |
Author_xml | – sequence: 1 givenname: M.M. surname: Abushady fullname: Abushady, M.M. email: manalabushady@med.asu.edu.eg organization: Internal Medicine & Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt – sequence: 2 givenname: M. surname: Samy fullname: Samy, M. organization: Internal Medicine & Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt – sequence: 3 givenname: M. surname: Bekhet fullname: Bekhet, M. organization: Internal Medicine & Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt – sequence: 4 givenname: A. surname: Abdullah fullname: Abdullah, A. organization: Internal Medicine Department in Specialized Damietta Hospital, Damietta, Egypt |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31195024$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_diabres_2020_108593 crossref_primary_10_3390_nu12082478 crossref_primary_10_1016_j_dsx_2020_07_033 crossref_primary_10_1371_journal_pone_0242111 crossref_primary_10_7759_cureus_57522 crossref_primary_10_4103_hmj_hmj_11_22 crossref_primary_10_1016_j_dsx_2022_102680 crossref_primary_10_1016_j_diabres_2020_108474 crossref_primary_10_1155_2023_2636507 crossref_primary_10_3389_fnut_2025_1434484 crossref_primary_10_1016_j_diabres_2021_109090 |
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Keywords | Type 2 diabetes ESRD T1DM T2DM DM Albuminuria Kidney functions SD DBP ANOVA BUN LSD UACR CKD BMI 2hPPG eGFR SBP MDRD Fasting Ramadan Fra Alb FPG HbA1C ADA |
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Snippet | To evaluate the effect of Ramadan fasting on kidney functions in patients with type 2 DM.
We recruited 90 subjects with type 2 DM intending to fast Ramadan;... To evaluate the effect of Ramadan fasting on kidney functions in patients with type 2 DM.AIMTo evaluate the effect of Ramadan fasting on kidney functions in... |
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SubjectTerms | Albuminuria Fasting Ramadan Kidney functions Type 2 diabetes |
Title | Effect of Ramadan fasting on renal function in patients with type 2 diabetes |
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