Transfection of the TRAIL gene into human mesenchymal stem cells using biocompatible polyethyleneimine carbon dots for cancer gene therapy
For effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), which is a protein that selectively induces cancer cell apoptosis through human mesenchymal stem cells (hMSCs), low cytotoxicity branched polyethyleneimine (bPEI) 25k carbon dots (bPEI25k CDs) were inve...
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| Published in | Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 80; pp. 722 - 728 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
25.12.2019
한국공업화학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-086X 1876-794X |
| DOI | 10.1016/j.jiec.2019.02.015 |
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| Abstract | For effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), which is a protein that selectively induces cancer cell apoptosis through human mesenchymal stem cells (hMSCs), low cytotoxicity branched polyethyleneimine (bPEI) 25k carbon dots (bPEI25k CDs) were investigated as a TRAIL–GFP gene (plasmid TRAIL–GFP, pTRAIL–GFP) carrier for delivery into hMSCs. bPEI25k CDs were prepared using one-step microwave-assisted pyrolysis, which has the advantage of low cytotoxicity and allows for bioimaging after gene delivery. The bPEI25k CDs had lower cytotoxicity levels at all tested concentrations, whereas the raw bPEI25k were cytotoxic in proportions up to a concentration by 25%. The complex containing bPEI25k CDs and pTRAIL–GFP was safely internalized and transfected into the hMSCs. It also revealed a cellular fluorescence imaging property induced by a unique characteristic of CDs. The amount of secreted TRAIL from bPEI25k CDs/pTRAIL–GFP@hMSCs was 25-fold higher than that from bPEI25k/pTRAIL–GFP@hMSCs, leading to a higher cytotoxic effect against the lung cancer cells. Therefore, bPEI25k CDs are recommended as an effective gene carrier for successful cancer gene therapy mediated through hMSCs. |
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| AbstractList | For effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), whichis a protein that selectively induces cancer cell apoptosis through human mesenchymal stem cells(hMSCs), low cytotoxicity branched polyethyleneimine (bPEI) 25k carbon dots (bPEI25k CDs) wereinvestigated as a TRAIL–GFP gene (plasmid TRAIL–GFP, pTRAIL–GFP) carrier for delivery into hMSCs.
bPEI25k CDs were prepared using one-step microwave-assisted pyrolysis, which has the advantage oflow cytotoxicity and allows for bioimaging after gene delivery. The bPEI25k CDs had lower cytotoxicitylevels at all tested concentrations, whereas the raw bPEI25k were cytotoxic in proportions up to aconcentration by 25%. The complex containing bPEI25k CDs and pTRAIL–GFP was safely internalized andtransfected into the hMSCs. It also revealed a cellularfluorescence imaging property induced by a uniquecharacteristic of CDs. The amount of secreted TRAIL from bPEI25k CDs/pTRAIL–GFP@hMSCs was 25-foldhigher than that from bPEI25k/pTRAIL–GFP@hMSCs, leading to a higher cytotoxic effect against the lungcancer cells. Therefore, bPEI25k CDs are recommended as an effective gene carrier for successful cancergene therapy mediated through hMSCs. KCI Citation Count: 8 For effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), which is a protein that selectively induces cancer cell apoptosis through human mesenchymal stem cells (hMSCs), low cytotoxicity branched polyethyleneimine (bPEI) 25k carbon dots (bPEI25k CDs) were investigated as a TRAIL–GFP gene (plasmid TRAIL–GFP, pTRAIL–GFP) carrier for delivery into hMSCs. bPEI25k CDs were prepared using one-step microwave-assisted pyrolysis, which has the advantage of low cytotoxicity and allows for bioimaging after gene delivery. The bPEI25k CDs had lower cytotoxicity levels at all tested concentrations, whereas the raw bPEI25k were cytotoxic in proportions up to a concentration by 25%. The complex containing bPEI25k CDs and pTRAIL–GFP was safely internalized and transfected into the hMSCs. It also revealed a cellular fluorescence imaging property induced by a unique characteristic of CDs. The amount of secreted TRAIL from bPEI25k CDs/pTRAIL–GFP@hMSCs was 25-fold higher than that from bPEI25k/pTRAIL–GFP@hMSCs, leading to a higher cytotoxic effect against the lung cancer cells. Therefore, bPEI25k CDs are recommended as an effective gene carrier for successful cancer gene therapy mediated through hMSCs. |
| Author | Na, Kun Han, Jieun |
| Author_xml | – sequence: 1 givenname: Jieun surname: Han fullname: Han, Jieun – sequence: 2 givenname: Kun surname: Na fullname: Na, Kun email: kna6997@catholic.ac.kr |
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| Cites_doi | 10.1002/smll.201701810 10.1158/0008-5472.CAN-08-4698 10.1016/j.biomaterials.2014.09.014 10.1016/j.gendis.2017.04.001 10.1021/acsami.5b10160 10.1002/mabi.201400463 10.1016/j.biomaterials.2012.05.040 10.1039/C5RA07968C 10.1002/pat.3432 10.1002/adhm.201500563 10.1038/nbt.2816 10.1021/acsami.5b00486 10.1016/j.biomaterials.2012.01.052 10.1016/j.carbon.2017.03.017 10.1016/j.jiec.2018.10.007 10.1016/j.colsurfb.2013.07.047 10.1016/j.tibtech.2015.11.004 10.1038/srep21170 10.1016/j.biomaterials.2013.08.012 10.1016/j.biomaterials.2018.08.024 10.1038/s41598-018-25330-x 10.1016/j.biomaterials.2013.05.072 10.3390/genes8020065 10.1002/adma.201505088 10.1021/am508994w 10.1021/acs.nanolett.7b00616 |
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| Snippet | For effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), which is a protein that selectively induces cancer cell... For effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), whichis a protein that selectively induces cancer cell... |
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| Title | Transfection of the TRAIL gene into human mesenchymal stem cells using biocompatible polyethyleneimine carbon dots for cancer gene therapy |
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