Expression and possible roles of activin A in proliferative vitreoretinal diseases
To examine the expression of activin A in eyes and to determine the possible functions of activin A in proliferative vitreoretinal diseases. The activin A concentration in vitreous specimens obtained from eyes with or without retinal ischemia was measured by a bioassay using erythroid differentiatio...
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Published in | Japanese journal of ophthalmology Vol. 44; no. 3; p. 221 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Japan
01.05.2000
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Subjects | |
Online Access | Get more information |
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Summary: | To examine the expression of activin A in eyes and to determine the possible functions of activin A in proliferative vitreoretinal diseases.
The activin A concentration in vitreous specimens obtained from eyes with or without retinal ischemia was measured by a bioassay using erythroid differentiation factor effects of activin A. The expression of activin A and activin receptors in the preretinal membranes was observed by immunohistochemical analysis.
The mean concentration of activin A in the eyes with proliferative diabetic retinopathy was 1. 50 +/- 1.27 ng/mL (mean +/- SD; n = 10), and that in the nondiabetic eyes without retinal ischemia (macular hole and epiretinal membrane) was 0.90 +/- 0.55 ng/mL (n = 5). Neither difference was significant. Activin A and its receptors were detected in the vascular endothelial cells, fibroblast-like cells and round-shaped macrophage-like cells in preretinal proliferative membranes by immunohistochemical analysis.
Activin A is involved in the proliferative membrane formation in both ischemic and nonischemic vitreoretinal proliferative diseases. Activin A, a member of TGF-beta superfamily, regulates angiogenesis and tissue fibrosis in the wound healing process. |
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ISSN: | 0021-5155 |
DOI: | 10.1016/S0021-5155(99)00216-6 |