Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies

• Published in: Natural product reports Vol. 24; no. 1; p. 109
• Main Authors: Dawson, Simon, Malkinson, John P, Paumier, David, Searcey, Mark
• Format: Journal Article
• Language: English
• Published: England 01.01.2007
• Subjects: Biological Products; Depsipeptides - chemistry; Depsipeptides - isolation & purification; Depsipeptides - pharmacology; DNA - metabolism; Echinomycin - chemistry; Echinomycin - isolation & purification; Echinomycin - pharmacology; Intercalating Agents; Peptides - chemistry; Peptides - isolation & purification; Peptides - pharmacology; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Peptides, Cyclic - pharmacology; Quinolines - chemistry; Quinolines - isolation & purification; Quinolines - pharmacology; Quinoxalines - chemistry; Quinoxalines - isolation & purification; Quinoxalines - pharmacology

Echinomycin is the prototypical bisintercalator, a molecule that binds to DNA by inserting two planar chromophores between the base-pairs of duplex DNA, placing its cyclic depsipeptide backbone in the minor groove. As such, it has been the focus of an extensive number of investigations into its biol...