Salvianolic acid A attenuates steroid resistant nephrotic syndrome through suPAR/uPAR-αvβ3 signaling Inhibition

• Published in: Journal of ethnopharmacology Vol. 279; no. NA; p. 114351
• Main Authors: Li, Xin, Qi, Dong, Wang, Meng-ying, Ji, Kai, Xie, Qun-ling, Wang, Yu, Du, Shi-hao, Fan, Hua-ying
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.10.2021
• Subjects: active ingredients; Adult; apoptosis; blood serum; Caffeic Acids - isolation & purification; Caffeic Acids - pharmacology; Case-Control Studies; doxorubicin; Female; flow cytometry; gene expression; glucocorticoids; Glucocorticoids - pharmacology; Humans; Idiopathic nephrotic syndrome; immunohistochemistry; Lactates - isolation & purification; Lactates - pharmacology; Male; Membrane Proteins - genetics; Middle Aged; nephrotic syndrome; Nephrotic Syndrome - drug therapy; Nephrotic Syndrome - genetics; Nephrotic Syndrome - physiopathology; Oriental traditional medicine; Podocytes - drug effects; Podocytes - metabolism; protective effect; Receptors, Glucocorticoid - genetics; Receptors, Urokinase Plasminogen Activator - genetics; Salvia miltiorrhiza; Salvia miltiorrhiza - chemistry; salvianolic acid; Salvianolic acid a; Signal Transduction - drug effects; Steroid resistant nephrotic syndrome; suPAR; urine; water solubility; Western blotting; Young Adult; Salvianolic acid a; suPAR; Steroid resistant nephrotic syndrome; Idiopathic nephrotic syndrome

Salvianolic acid A (SAA) is extracted from traditional Chinese medicine Salvia miltiorrhiza and is the main water-soluble and the biologically active ingredient. SAA possesses a variety of pharmacological activities and has an excellent protective effect on kidney disease, especially steroid resista...