Biomarker Phenotypes in Heart Failure with Preserved Ejection Fraction Using Hierarchical Clustering: A Pilot Study

• Published in: Medical principles and practice Vol. 32; no. 4-5; pp. 297 - 307
• Main Authors: Mitic, Valentina, Stojanovic, Dijana, Deljanin Ilic, Marina, Petrovic, Dejan, Ignjatovic, Aleksandra, Milenkovic, Jelena
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.11.2023
• Subjects: Biomarkers; Clustering; Cysts; Ejection fraction; Electrocardiography; Flow velocity; Genotype & phenotype; Heart failure; Heart rate; Machine learning; Original Paper; Patients; Plasma; Population; Pulmonary arteries; Rehabilitation; United Kingdom > UK; United States > US; Heart failure with a preserved ejection fraction; Phenomapping; Hierarchical clustering; Cardiac remodeling biomarkers; Cystatin C

Objectives: We hypothesized the existence of distinct phenotype-based groups within the very heterogeneous population of patients of heart failure with preserved ejection fraction (HFpEF) and using an unsupervised hierarchical clustering applied to plasma concentration of various biomarkers. We soug...