Is Soluble Mesothelin-Related Protein an Upfront Predictive Marker of Pleural Mesothelioma? A Prospective Study on Italian Workers Exposed to Asbestos

• Published in: Oncology Vol. 86; no. 1; pp. 33 - 43
• Main Authors: Filiberti, Rosa, Marroni, Paola, Spigno, Fabio, Merlo, Domenico F., Mortara, Virginia, Caruso, Pietro, Cioè, Alex, Michelazzi, Luigi, Bruzzone, Andrea, Bobbio, Barbara, Simonassi, Claudio, Del Corso, Lisette, Galli, Roberto, Racchi, Omar, Dini, Guglielmo, Linares, Roberta, Mencoboni, Manlio
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2014
• Subjects: Aged; Asbestos; Asbestos - adverse effects; Biomarkers, Tumor - blood; Clinical Translational Research; Epidemiology; Follow-Up Studies; GPI-Linked Proteins - blood; Humans; Lung cancer; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; Mesothelioma - blood; Mesothelioma - diagnosis; Mesothelioma, Malignant; Middle Aged; Occupational Exposure; Occupational hazards; Pleural Neoplasms - blood; Pleural Neoplasms - diagnosis; Prospective Studies; Proteins; Mesothelin; Asbestos exposure; Malignant pleural mesothelioma

Objective: Soluble mesothelin-related peptide (SMRP) may be useful in the diagnosis and detection of early stage mesothelioma. We investigated the SMRP upfront predictive role for mesothelioma in asbestos-exposed workers. Methods: A total of 1,715 subjects underwent a first visit and were invited fo...