Genistein Attenuated Allergic Airway Inflammation by Modulating the Transcription Factors T-bet, GATA-3 and STAT-6 in a Murine Model of Asthma

• Published in: Pharmacology Vol. 89; no. 3-4; pp. 229 - 236
• Main Authors: Gao, Fei, Wei, Dong, Bian, Tao, Xie, Ping, Zou, Jian, Mu, Huijun, Zhang, Bin, Zhou, Xiaoyan
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2012
• Subjects: Allergens - immunology; Allergies; Animals; Anti-Allergic Agents - therapeutic use; Anti-Inflammatory Agents - therapeutic use; Asthma; Asthma - drug therapy; Asthma - immunology; Asthma - pathology; Bronchoalveolar Lavage Fluid - immunology; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; Cells, Cultured; Cytokines; Cytokines - blood; Cytokines - immunology; Disease Models, Animal; GATA3 Transcription Factor - genetics; GATA3 Transcription Factor - immunology; Gene expression; Genistein - therapeutic use; Male; Mice; Mice, Inbred BALB C; Original Paper; Ovalbumin - immunology; Phytochemicals; RNA, Messenger - immunology; Rodents; STAT6 Transcription Factor - genetics; STAT6 Transcription Factor - immunology; T-Box Domain Proteins - genetics; T-Box Domain Proteins - immunology; Transcription factor; Genistein; Cytokine; Asthma

Background: Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. Previous studies have shown that genistein decreased airway inflammation in allergic asthma. However, studies on how genistein affects immunoreactions in asthma are very limited. Objective: It wa...