Lipid Solubility and Molecular Weight: Whose Idea Was That

Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative struc...

Full description

Saved in:
Bibliographic Details
Published inSkin pharmacology and physiology Vol. 26; no. 4-6; pp. 295 - 301
Main Author Kasting, G.B.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2013
Subjects
Administration, Cutaneous
Cooper Eugene Rex
Drug Design
Eugene Rex Cooper
Further Section
History, 20th Century
History, 21st Century
Humans
Models, Biological
Molecular Weight
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Quantitative Structure-Activity Relationship
Skin - metabolism
Skin Absorption
Solubility
Skin permeability
Cooper, Gene
Quantitative structure-penetration relationship
Finite dose
Penetration enhancer
Online AccessGet full text

Cover

Abstract Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative structure-penetration relationships for chemicals contacting human skin. His ideas regarding the impact of molecular weight and lipid solubility on skin transport catalyzed the later development by Potts and Guy of the first successful skin permeability model. But Gene's most important contribution to the field was as a scientific role model and an inspirational leader who launched the careers of several young scientists, including the author of this article.
AbstractList Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative structure-penetration relationships for chemicals contacting human skin. His ideas regarding the impact of molecular weight and lipid solubility on skin transport catalyzed the later development by Potts and Guy of the first successful skin permeability model. But Gene's most important contribution to the field was as a scientific role model and an inspirational leader who launched the careers of several young scientists, including the author of this article. © 2013 S. Karger AG, Basel [PUBLICATION ABSTRACT]
Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative structure-penetration relationships for chemicals contacting human skin. His ideas regarding the impact of molecular weight and lipid solubility on skin transport catalyzed the later development by Potts and Guy of the first successful skin permeability model. But Gene's most important contribution to the field was as a scientific role model and an inspirational leader who launched the careers of several young scientists, including the author of this article.
Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative structure-penetration relationships for chemicals contacting human skin. His ideas regarding the impact of molecular weight and lipid solubility on skin transport catalyzed the later development by Potts and Guy of the first successful skin permeability model. But Gene's most important contribution to the field was as a scientific role model and an inspirational leader who launched the careers of several young scientists, including the author of this article.Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his career. His work led to the development of finite dose skin absorption models, chemical penetration enhancer technologies and quantitative structure-penetration relationships for chemicals contacting human skin. His ideas regarding the impact of molecular weight and lipid solubility on skin transport catalyzed the later development by Potts and Guy of the first successful skin permeability model. But Gene's most important contribution to the field was as a scientific role model and an inspirational leader who launched the careers of several young scientists, including the author of this article.
Author Kasting, G.B.
Author_xml – sequence: 1
  givenname: G.B.
  surname: Kasting
  fullname: Kasting, G.B.
  email: Gerald.Kasting@uc.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23921116$$D View this record in MEDLINE/PubMed
BookMark eNpt0TtPwzAQB3ADRfRBB3aEIrHAEOqLH4m7oYpHpSIGijpGbuK0Lmlc7GTot8eopUPF5OF-d_7rrotalakUQleAHwCYGGCMCQPB-AnqizghBBIc0Yglp6gDnOOQMcLOUPevQGnrUIjiNuo6t8I44jHwC9SOiIgAgHfQcKI3Og8-TNnMdanrbSCrPHgzpcqaUtpgpvRiWQ-D2dI4FYxzJYOZdMF0KetLdF7I0qn-_u2hz-en6eg1nLy_jEePkzAjhNYhxaLwETIpBQEigOAiyymLogRzBYz4UETOYyFIIhMOcwZZnvuAisuCCiVID93t5m6s-W6Uq9O1dpkqS1kp07gUKCSccsDE09sjujKNrXw6r_w_cUwJ9upmr5r5WuXpxuq1tNv0byse3O9AZo1zVhUHAjj9PUd6OIe3gyOb6VrW2lS1lbr8t-N61_El7ULZw-x9-QffDYq9
CitedBy_id crossref_primary_10_1016_j_addr_2021_113929
crossref_primary_10_1016_j_ijpharm_2017_03_048
crossref_primary_10_1016_j_ijpharm_2017_11_042
crossref_primary_10_1371_journal_pone_0137890
crossref_primary_10_1016_j_xphs_2018_10_026
crossref_primary_10_1016_j_ejpb_2016_04_018
crossref_primary_10_3390_biomedicines11030664
Cites_doi 10.1002/jps.2600750513
10.1111/1523-1747.ep12277592
10.1016/0045-6535(95)00023-2
10.1002/jps.2600741018
10.1002/jps.2600820525
10.1007/978-1-4613-3494-1_51
10.1002/jps.2600740623
10.1016/j.jconrel.2009.10.006
10.1016/0021-9797(74)90199-4
10.1016/0168-3659(87)90061-7
10.1002/jps.2600700110
10.1016/0378-5173(87)90238-9
10.1023/A:1015810312465
10.1002/jps.2600730916
10.1002/aic.690210522
10.1002/jps.2600730831
10.1023/A:1018981515480
10.1016/S0376-7388(00)80886-8
10.1016/0168-3659(84)90007-5
10.1016/S0376-7388(00)80100-3
10.1016/0168-3659(84)90008-7
10.1023/A:1015989929342
10.1023/A:1015956705293
10.1063/1.1679819
10.1002/jps.2600501018
ContentType Journal Article
Copyright 2013 S. Karger AG, Basel
2013 S. Karger AG, Basel.
Copyright (c) 2013 S. Karger AG, Basel
Copyright_xml – notice: 2013 S. Karger AG, Basel
– notice: 2013 S. Karger AG, Basel.
– notice: Copyright (c) 2013 S. Karger AG, Basel
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QO
7U7
7X7
7XB
88E
8AO
8FD
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
C1K
CCPQU
FR3
FYUFA
GHDGH
K9.
M0S
M1P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
DOI 10.1159/000351956
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Toxicology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central
Environmental Sciences and Pollution Management
ProQuest One Community College
Engineering Research Database
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Pharma Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Toxicology Abstracts
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Technology Research Database
MEDLINE
CrossRef

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISBN 9783318024258
3318024252
EISSN 1660-5535
EndPage 301
ExternalDocumentID 3049542381
23921116
10_1159_000351956
351956
Genre Biography
Historical Article
Portraits
Journal Article
GroupedDBID ---
0R~
0~5
0~B
123
1CY
30W
328
3O.
3V.
4.4
53G
7X7
88E
8AO
8FI
8FJ
AAYIC
ABJNI
ABPAZ
ABUWG
ACGFO
ACGFS
ACIWK
ACPRK
ACPSR
ADBBV
AENEX
AEYAO
AFJJK
AFKRA
AFRAH
AHMBA
ALDHI
ALMA_UNASSIGNED_HOLDINGS
AZPMC
BENPR
BPHCQ
BVXVI
CAG
CCPQU
COF
CYUIP
DU5
E0A
EBS
EJD
EMOBN
F5P
FB.
FYUFA
HMCUK
HZ~
IAO
IHR
IY7
KUZGX
M1P
O1H
O9-
P2P
PQQKQ
PROAC
PSQYO
RKO
RXVBD
UJ6
UKHRP
AAYXX
ABBTS
ABWCG
AHFRZ
CITATION
ITC
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7QO
7U7
7XB
8FD
8FK
C1K
FR3
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
PUEGO
7X8
ID FETCH-LOGICAL-c334t-409f527caa93139130fcd4522806e1530263ab79938a861b51cdd239e6af49e93
IEDL.DBID 7X7
ISBN 3318024244
9783318024241
ISSN 1660-5527
1660-5535
IngestDate Fri Jul 11 00:10:33 EDT 2025
Sat Aug 23 12:36:03 EDT 2025
Thu Apr 03 07:07:37 EDT 2025
Thu Apr 24 22:53:19 EDT 2025
Tue Jul 01 04:49:55 EDT 2025
Thu Aug 29 12:04:27 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 4-6
Keywords Skin permeability
Cooper, Gene
Quantitative structure-penetration relationship
Finite dose
Penetration enhancer
Language English
License Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
https://www.karger.com/Services/SiteLicenses
2013 S. Karger AG, Basel.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c334t-409f527caa93139130fcd4522806e1530263ab79938a861b51cdd239e6af49e93
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Biography-3
ObjectType-Article-2
ObjectType-Biography-1
ObjectType-Feature-3
content type line 23
ObjectType-Undefined-4
PMID 23921116
PQID 1426377430
PQPubID 29225
PageCount 7
ParticipantIDs karger_primary_351956
pubmed_primary_23921116
proquest_miscellaneous_1418646103
proquest_journals_1426377430
crossref_primary_10_1159_000351956
crossref_citationtrail_10_1159_000351956
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-01-01
PublicationDateYYYYMMDD 2013-01-01
PublicationDate_xml – month: 01
  year: 2013
  text: 2013-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Basel, Switzerland
PublicationPlace_xml – name: Basel, Switzerland
– name: Switzerland
– name: Basel
PublicationTitle Skin pharmacology and physiology
PublicationTitleAlternate Skin Pharmacol Physiol
PublicationYear 2013
Publisher S. Karger AG
Publisher_xml – name: S. Karger AG
References Collander R, Barlund H: Permeability in chara certophylla. II. Permeability to nonelectrolytes. Acta Botan Fenn 1930;2:1-114.
Cooper ER: Effect of substituents on benzoic acid transport across human skin in vitro. J Control Rel 1984;1:153-156.10.1016/0168-3659(84)90008-7
Berner B, Cooper ER: Asymptotic solution for nonsteady-state diffusion through oil-water multilaminates. J Membr Sci 1983;14:139-145.10.1016/S0376-7388(00)80100-3
Kasting GB, Smith RL, Anderson BD: Prodrugs for dermal delivery: solubility, molecular size, and functional group effects; in Sloan KB (ed) Prodrugs: Topical and Ocular Drug Delivery. New York, Dekker, 1992, pp 117-161.
Cooper ER, Berner B: Effect of decylmethyl sulfoxide on skin penetration; in Mittal KL, Fendler EJ (eds): Solution Behavior of Surfactants: Theoretical and Applied Aspects. New York, Plenum Press, 1982.10.1007/978-1-4613-3494-1_51
Wilschut A, ten Berge WF, Robinson PJ, McKone TE: Estimating skin permeation. The validation of five mathematical skin penetration models. Chemosphere 1995;30:1275-1296.774972310.1016/0045-6535(95)00023-2
Cooper ER: Pharmacy International 1986;December:308-310.
Wu X, Keister JC, Cooper ER: Theoretical effects of binding on transport lag times in the case of multilayered membranes. J Membr Sci 1990;50:57-69.10.1016/S0376-7388(00)80886-8
Berner B, Cooper ER: Desorption out of an oil-water multilaminate membrane. J Control Rel 1984;1:149-152.10.1016/0168-3659(84)90007-5
Higuchi T: Rate of release of medicaments from ointment bases containing drugs in suspensions. J Pharm Sci 1961;50:874-875.1390726910.1002/jps.2600501018
Cooper ER, Berner B: Skin permeability; in Skerrow D, Skerrow CJ (eds): Methods in Skin Research. New York, Wiley & Sons, 1985, pp 407-432.
Cooper ER, Berner B, Bruce RD: Kinetic analysis of relationship between partition coefficient and biological response. J Pharm Sci 1981;70:57-59.722993010.1002/jps.2600700110
Bronaugh RL, Stewart RF: Methods for in vitro percutaneous absorption studies. VI. Preparation of the barrier layer. J Pharm Sci 1986;75:487-491.373508810.1002/jps.2600750513
Cooper ER: Nanoparticles: a personal experience for formulating poorly water soluble drugs. J Control Release 2010;141:300-302.1982217710.1016/j.jconrel.2009.10.006
Kasting GB, Smith RL, Cooper ER: Effect of lipid solubility and molecular size on percutaneous absorption. Skin Pharmacol 1987;1:138-153.
Cooper ER, Dahler JS, Verlin JD, Matzen MK, Hoffman DK: Model calculations of magnetic field effects on diffusion and thermal diffusion coefficients of binary gas mixtures. J Chem Phys 1973;59:403-408.10.1063/1.1679819
Cooper ER, Merritt EW, Smith RL: Effect of fatty acids and alcohols on the penetration of acyclovir across human skin in vitro. J Pharm Sci 1985;74:688-689.402065710.1002/jps.2600740623
Cooper ER: Increased skin permeability for lipophilic molecules. J Pharm Sci 1984;73:1153-1156.649192210.1002/jps.2600730831
Raykar PV, Fung M-C, Anderson BD: The role of protein and lipid domains in the uptake of solutes by human stratum corneum. Pharm Res 1988;5:140-150.324462510.1023/A:1015956705293
Michaels AS, Chandrasekaran SK, Shaw JE: Drug permeation through human skin: theory and in vitro experimental measurement. Am Inst Chem Eng J 1975;21:985-996.10.1002/aic.690210522
Cooper ER, Berner B: Finite dose pharmacokinetics of skin penetration. J Pharm Sci 1985;74:1100-1102.407871010.1002/jps.2600741018
Cooper ER: Effect of adsorption on membrane diffusion. J Colloid Interface Sci 1974;48:516-517.10.1016/0021-9797(74)90199-4
Ackermann C, Flynn GL, Smith WM: Ether-water partitioning and permeability through nude mouse skin in vitro. II. Hydrocortisone 21-n-alkyl esters, alkanols and hydrophilic compounds. Int J Pharm 1987;36:67-71.10.1016/0378-5173(87)90238-9
Bronaugh RL, Stewart RF: Methods for in vitro percutaneous absorption studies. III. Hydrophobic compounds. J Pharm Sci 1984;73:1255-1258.649194510.1002/jps.2600730916
Cooper ER, Loomans ME, Fawzi MB: Penetrating topical pharmaceutical compositions containing corticosteroids. US patent No 4552872. November 12, 1985. Cincinnati, Procter & Gamble.
Cooper ER, Loomans ME, Wickett RR: Penetrating topical pharmaceutical compositions. US patent No 4954487. September 4, 1990. Cincinnati, Procter & Gamble.
Cooper ER, Kasting GB: Transport across epithelial membranes. J Control Release 1987;6:23-35.10.1016/0168-3659(87)90061-7
Cooper ER: Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one. US patent No 4557934. December 10, 1985. Cincinnati, Procter & Gamble.
Flynn GL: Physicochemical determinants of skin absorption; in Gerrity TR, Henry CJ (eds): Principles of Route-to-Route Extrapolation for Risk Assessment. New York, Elsevier Science, 1990, pp 93-127.
Anderson BD, Higuchi WI, Raykar PV: Heterogeneity effects on permeability-partition coefficient relationships in human stratum corneum. Pharm Res 1988;5:566-573.324731910.1023/A:1015989929342
Anderson BD, Raykar PV: Solute structure-permeability relationships in human stratum corneum. J Invest Dermatol 1989;93:280-286.275427710.1111/1523-1747.ep12277592
Cleek RL, Bunge AL: A new method for estimating dermal absorption from chemical exposure. 1. General approach. Pharm Res 1993;10:497-506.848383110.1023/A:1018981515480
Cooper ER: Penetrating topical pharmaceutical compositions containing n-(2-hydroxyethyl) pyrrolidone. US patent No 4537776. August 27, 1985. Cincinnati, Procter & Gamble.
Kasting GB, Francis WR, Roberts GE: Skin penetration enhancement of triprolidine base by propylene glycol. J Pharm Sci 1993;82:551-552.836083710.1002/jps.2600820525
Potts RO, Guy RH: Predicting skin permeability. Pharm Res 1992;9:663-669.160890010.1023/A:1015810312465
Cooper ER: Diffusional lag time asymmetry for membranes which possess heterogeneous adsorptive capacities. J Colloid Interface Sci 1975;51:538-539.
Higuchi T: Physical chemical analysis of percutaneous absorption process from creams and ointments. J Soc Cosmet Chem 1960;11:85-97.
ref13
ref12
ref15
ref14
ref11
ref10
ref2
ref1
ref17
ref16
ref19
ref18
ref24
ref23
ref25
ref20
ref22
ref21
ref8
ref7
ref9
ref4
ref3
ref6
ref5
References_xml – reference: Anderson BD, Higuchi WI, Raykar PV: Heterogeneity effects on permeability-partition coefficient relationships in human stratum corneum. Pharm Res 1988;5:566-573.324731910.1023/A:1015989929342
– reference: Cooper ER, Kasting GB: Transport across epithelial membranes. J Control Release 1987;6:23-35.10.1016/0168-3659(87)90061-7
– reference: Kasting GB, Smith RL, Cooper ER: Effect of lipid solubility and molecular size on percutaneous absorption. Skin Pharmacol 1987;1:138-153.
– reference: Cooper ER: Nanoparticles: a personal experience for formulating poorly water soluble drugs. J Control Release 2010;141:300-302.1982217710.1016/j.jconrel.2009.10.006
– reference: Michaels AS, Chandrasekaran SK, Shaw JE: Drug permeation through human skin: theory and in vitro experimental measurement. Am Inst Chem Eng J 1975;21:985-996.10.1002/aic.690210522
– reference: Berner B, Cooper ER: Asymptotic solution for nonsteady-state diffusion through oil-water multilaminates. J Membr Sci 1983;14:139-145.10.1016/S0376-7388(00)80100-3
– reference: Collander R, Barlund H: Permeability in chara certophylla. II. Permeability to nonelectrolytes. Acta Botan Fenn 1930;2:1-114.
– reference: Wu X, Keister JC, Cooper ER: Theoretical effects of binding on transport lag times in the case of multilayered membranes. J Membr Sci 1990;50:57-69.10.1016/S0376-7388(00)80886-8
– reference: Anderson BD, Raykar PV: Solute structure-permeability relationships in human stratum corneum. J Invest Dermatol 1989;93:280-286.275427710.1111/1523-1747.ep12277592
– reference: Cooper ER: Penetrating topical pharmaceutical compositions containing n-(2-hydroxyethyl) pyrrolidone. US patent No 4537776. August 27, 1985. Cincinnati, Procter & Gamble.
– reference: Bronaugh RL, Stewart RF: Methods for in vitro percutaneous absorption studies. VI. Preparation of the barrier layer. J Pharm Sci 1986;75:487-491.373508810.1002/jps.2600750513
– reference: Cooper ER, Berner B, Bruce RD: Kinetic analysis of relationship between partition coefficient and biological response. J Pharm Sci 1981;70:57-59.722993010.1002/jps.2600700110
– reference: Cooper ER, Berner B: Effect of decylmethyl sulfoxide on skin penetration; in Mittal KL, Fendler EJ (eds): Solution Behavior of Surfactants: Theoretical and Applied Aspects. New York, Plenum Press, 1982.10.1007/978-1-4613-3494-1_51
– reference: Cooper ER: Pharmacy International 1986;December:308-310.
– reference: Ackermann C, Flynn GL, Smith WM: Ether-water partitioning and permeability through nude mouse skin in vitro. II. Hydrocortisone 21-n-alkyl esters, alkanols and hydrophilic compounds. Int J Pharm 1987;36:67-71.10.1016/0378-5173(87)90238-9
– reference: Higuchi T: Rate of release of medicaments from ointment bases containing drugs in suspensions. J Pharm Sci 1961;50:874-875.1390726910.1002/jps.2600501018
– reference: Cooper ER: Effect of substituents on benzoic acid transport across human skin in vitro. J Control Rel 1984;1:153-156.10.1016/0168-3659(84)90008-7
– reference: Raykar PV, Fung M-C, Anderson BD: The role of protein and lipid domains in the uptake of solutes by human stratum corneum. Pharm Res 1988;5:140-150.324462510.1023/A:1015956705293
– reference: Cooper ER: Increased skin permeability for lipophilic molecules. J Pharm Sci 1984;73:1153-1156.649192210.1002/jps.2600730831
– reference: Cleek RL, Bunge AL: A new method for estimating dermal absorption from chemical exposure. 1. General approach. Pharm Res 1993;10:497-506.848383110.1023/A:1018981515480
– reference: Cooper ER, Loomans ME, Wickett RR: Penetrating topical pharmaceutical compositions. US patent No 4954487. September 4, 1990. Cincinnati, Procter & Gamble.
– reference: Cooper ER, Merritt EW, Smith RL: Effect of fatty acids and alcohols on the penetration of acyclovir across human skin in vitro. J Pharm Sci 1985;74:688-689.402065710.1002/jps.2600740623
– reference: Berner B, Cooper ER: Desorption out of an oil-water multilaminate membrane. J Control Rel 1984;1:149-152.10.1016/0168-3659(84)90007-5
– reference: Cooper ER: Effect of adsorption on membrane diffusion. J Colloid Interface Sci 1974;48:516-517.10.1016/0021-9797(74)90199-4
– reference: Cooper ER: Diffusional lag time asymmetry for membranes which possess heterogeneous adsorptive capacities. J Colloid Interface Sci 1975;51:538-539.
– reference: Kasting GB, Smith RL, Anderson BD: Prodrugs for dermal delivery: solubility, molecular size, and functional group effects; in Sloan KB (ed) Prodrugs: Topical and Ocular Drug Delivery. New York, Dekker, 1992, pp 117-161.
– reference: Higuchi T: Physical chemical analysis of percutaneous absorption process from creams and ointments. J Soc Cosmet Chem 1960;11:85-97.
– reference: Kasting GB, Francis WR, Roberts GE: Skin penetration enhancement of triprolidine base by propylene glycol. J Pharm Sci 1993;82:551-552.836083710.1002/jps.2600820525
– reference: Wilschut A, ten Berge WF, Robinson PJ, McKone TE: Estimating skin permeation. The validation of five mathematical skin penetration models. Chemosphere 1995;30:1275-1296.774972310.1016/0045-6535(95)00023-2
– reference: Cooper ER, Berner B: Finite dose pharmacokinetics of skin penetration. J Pharm Sci 1985;74:1100-1102.407871010.1002/jps.2600741018
– reference: Cooper ER, Loomans ME, Fawzi MB: Penetrating topical pharmaceutical compositions containing corticosteroids. US patent No 4552872. November 12, 1985. Cincinnati, Procter & Gamble.
– reference: Flynn GL: Physicochemical determinants of skin absorption; in Gerrity TR, Henry CJ (eds): Principles of Route-to-Route Extrapolation for Risk Assessment. New York, Elsevier Science, 1990, pp 93-127.
– reference: Cooper ER, Berner B: Skin permeability; in Skerrow D, Skerrow CJ (eds): Methods in Skin Research. New York, Wiley & Sons, 1985, pp 407-432.
– reference: Cooper ER, Dahler JS, Verlin JD, Matzen MK, Hoffman DK: Model calculations of magnetic field effects on diffusion and thermal diffusion coefficients of binary gas mixtures. J Chem Phys 1973;59:403-408.10.1063/1.1679819
– reference: Bronaugh RL, Stewart RF: Methods for in vitro percutaneous absorption studies. III. Hydrophobic compounds. J Pharm Sci 1984;73:1255-1258.649194510.1002/jps.2600730916
– reference: Potts RO, Guy RH: Predicting skin permeability. Pharm Res 1992;9:663-669.160890010.1023/A:1015810312465
– reference: Cooper ER: Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one. US patent No 4557934. December 10, 1985. Cincinnati, Procter & Gamble.
– ident: ref19
  doi: 10.1002/jps.2600750513
– ident: ref6
  doi: 10.1111/1523-1747.ep12277592
– ident: ref23
  doi: 10.1016/0045-6535(95)00023-2
– ident: ref12
  doi: 10.1002/jps.2600741018
– ident: ref20
  doi: 10.1002/jps.2600820525
– ident: ref13
  doi: 10.1007/978-1-4613-3494-1_51
– ident: ref15
  doi: 10.1002/jps.2600740623
– ident: ref25
  doi: 10.1016/j.jconrel.2009.10.006
– ident: ref8
  doi: 10.1016/0021-9797(74)90199-4
– ident: ref21
  doi: 10.1016/0168-3659(87)90061-7
– ident: ref9
  doi: 10.1002/jps.2600700110
– ident: ref2
  doi: 10.1016/0378-5173(87)90238-9
– ident: ref5
  doi: 10.1023/A:1015810312465
– ident: ref18
  doi: 10.1002/jps.2600730916
– ident: ref1
  doi: 10.1002/aic.690210522
– ident: ref14
  doi: 10.1002/jps.2600730831
– ident: ref22
  doi: 10.1023/A:1018981515480
– ident: ref24
  doi: 10.1016/S0376-7388(00)80886-8
– ident: ref11
  doi: 10.1016/0168-3659(84)90007-5
– ident: ref10
  doi: 10.1016/S0376-7388(00)80100-3
– ident: ref17
  doi: 10.1016/0168-3659(84)90008-7
– ident: ref3
  doi: 10.1023/A:1015989929342
– ident: ref4
  doi: 10.1023/A:1015956705293
– ident: ref7
  doi: 10.1063/1.1679819
– ident: ref16
  doi: 10.1002/jps.2600501018
RelatedPersons Eugene Rex ER Cooper
Eugene Rex Cooper
Cooper Eugene Rex
RelatedPersons_xml – fullname: Eugene Rex ER Cooper
– fullname: Eugene Rex Cooper
– fullname: Cooper Eugene Rex
SSID ssj0026716
Score 2.0232537
Snippet Gene Cooper was a bright theoretician, a skilled product developer, and a motivational leader who applied his talents to the skin science area early in his...
SourceID proquest
pubmed
crossref
karger
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 295
SubjectTerms Administration, Cutaneous
Cooper Eugene Rex
Drug Design
Eugene Rex Cooper
Further Section
History, 20th Century
History, 21st Century
Humans
Models, Biological
Molecular Weight
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Quantitative Structure-Activity Relationship
Skin - metabolism
Skin Absorption
Solubility
Title Lipid Solubility and Molecular Weight: Whose Idea Was That
URI https://karger.com/doi/10.1159/000351956
https://www.ncbi.nlm.nih.gov/pubmed/23921116
https://www.proquest.com/docview/1426377430
https://www.proquest.com/docview/1418646103
Volume 26
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NS8MwFH_oJuJF_HY6RxQPXorL0qatHobKxhQ2RDa2W0mbFEHpdB8H_3vz0rTzoF7bRyDvJXmf_H4AlynH91BRJ1UydlyRuk6MY39K-oHLEs-LDdp-f8B7I_dp4k1swW1uxyqLN9E81HKaYI38miKyuI5VWLP98ekgaxR2Vy2FxjpUEboMR7r8ySrh4r6hPqWcNx1EGrPIQtqDX-cttBB5q3_4o403HL-e_R1tGq_T3YFtGy6Su9y-u7Cmsj3Y7NuG-D7cIve0JFjcMlOuX0RkkvQLzlsyNpXPGzJ-nc4VeZRKkLGYk-GrWLQPYNTtDB96juVDcBLG3IVO9cJU7yIRImQ6cNPeJ00kIqIHTa4o0v9wJmJfRxyBCDjVWk6kbLFQcW2CUIXsECrZNFPHQBRtSSkCoa2hQxKPBqGrEt_zsTGrcwyvBleFVqLEgoUjZ8V7ZJIGL4xKBdbgohT9yBEyfhM6yFVbihTf64WmI3t55tHK1DU4L3_rY4-9DJGp6RJlaMARK57V4Ci3ULm03rJOayk_-X_xU9hqGW4LrKfUobKYLdWZjjAWccMcowZU7zuD55dvYXPKAw
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9swED-hdmJ7mTZgrFsHBoHES0QdJ04yNFV8qgVaTaiovAUndlQJlDLaCvWf4m_kLl_wwHjjNTlZ8fl8vvNdfj-ArUSSPzTcSoyOLEcljhVR25_Rnu-I2HWjDG2_15edS-f0yr1agMfyXxhqqyx9Yuao9TimO_JdTsjiGKuIVvvun0WsUVRdLSk0crM4M_MHTNkmf7pHuL7btn1yPDjsWAWrgBUL4UwxYQoS1_ZipQKB4Q_68CTWhCvut6ThRKIjhYo8PLd95UuO3xprbYvASJxIYAh8CV1-3RGYytSgfnDc_3tRpXjSy8hWuZQti7DNCiwjjBl286JdQEzZL07ADzfU8H3___g2O-dOvsDnIkBl-7lFfYUFky7BYq8owS_DHrFda0bXaVlf7ZypVLNeybLLhtld6282HI0nhnW1UWyoJmwwUtP2Cly-i66-QS0dp-Y7MMNtrZWvcP0xCHK5Hzgm9lyPSsGY1bgN2Cm1EsYFPDmxZNyGWZriBmGlwAZsVqJ3OSbHa0IruWorkfJ5s9R0WGzXSfhsXA3YqF7jRqPqiUrNeEYy3JeETi8asJqvUDU0ThkTaS5_vD34OnzsDHrn4Xm3f_YTPtkZswbd5jShNr2fmV8Y30yjtcKoGFy_tx0_Af8KBKE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lipid+Solubility+and+Molecular+Weight%3A+Whose+Idea+Was+That%3F&rft.jtitle=Skin+pharmacology+and+physiology&rft.au=Kasting%2C+G+B&rft.date=2013-01-01&rft.pub=S.+Karger+AG&rft.issn=1660-5527&rft.eissn=1660-5535&rft.volume=26&rft.issue=4-6&rft.spage=295&rft_id=info:doi/10.1159%2F000351956&rft.externalDocID=3049542381
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1660-5527&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1660-5527&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1660-5527&client=summon