LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223–3p/NRP1 axis

• Published in: Behavioural brain research Vol. 431; p. 113923
• Main Authors: Liu, Lin, Zhou, Tingting, Li, Tao, Liang, Zhanhua, Luo, Xiaoguang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.08.2022
• Subjects: Inflammatory reaction; LncRNA DLX6-AS1; Microglia; MiR-223–3p; Neurological function; NLRP3; NRP1; Parkinson's disease; NRP1; Neurological function; LncRNA DLX6-AS1; Parkinson's disease; MiR-223–3p; NLRP3; Inflammatory reaction; Microglia; miR-223-3p

Parkinson's disease (PD) is a prevailing neurodegenerative disorder. This study discussed the mechanism of lncRNA distal-less homeobox 6 antisense 1 (DLX6-AS1) on inflammatory responses in PD. With healthy male C57BL/6 mice (8–10 weeks) and BV2 microglia as study subjects, we established PD mod...