Absorption mechanism of cyclosporine A loaded pH-sensitive nanoparticles in rats

• Published in: Journal of nanoscience and nanotechnology Vol. 8; no. 5; p. 2422
• Main Authors: Wang, Xue-Qing, Dai, Jun-Dong, Zhang, Hua, Zhang, Xuan, Wang, Jian-Cheng, Zhang, Qiang
• Format: Journal Article
• Language: English
• Published: United States 01.05.2008
• Subjects: Administration, Oral; Animals; Caco-2 Cells; Cyclosporine - administration & dosage; Cyclosporine - pharmacokinetics; Humans; Hydrogen-Ion Concentration; Nanoparticles; Rats

CyA was prepared into CyA Eudragit S100 nanoparticles (CyA-S100 NP) and the mechanisms of CyA-S100 NP improving the CyA absorption in gastrointestinal tract (GI) were studied systematically in rats. In the GI distribution study, the emptying rates of CyA-S100 NP in duodenum, jejunum, ileum and colon...