Functional composite nanofibers loaded with β-TCP and SIM as a control drug delivery system

• Published in: Materials letters Vol. 240; pp. 25 - 29
• Main Authors: Rezk, Abdelrahman I., Hwang, Tae In, Kim, Ju Yeon, Lee, Ji Yeon, Park, Chan Hee, Kim, Cheol Sang
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2019; Elsevier BV
• Subjects: Apatite; Biocompatibility; Biomedical materials; Body fluids; Bones; Buffer solutions; Calcium phosphates; Composite nanofibers; Computer simulation; Control drug delivery; Drug delivery systems; Emission analysis; In vitro methods and tests; Materials science; Mineralization; Morphology; Nanofibers; Regeneration; Scanning electron microscopy; Simvastatin; Surgical implants; Sustained release; Tissue engineering; Control drug delivery; Mineralization; Composite nanofibers; Simvastatin
• ISSN: 0167-577X; 1873-4979
• DOI: 10.1016/j.matlet.2018.12.107

[Display omitted] •Incorporation proper amount of SIM and β-TCP particles into the FCN mat improved the biomineralization process.•Kopcha model used to study kinetics of the drug release.•The FCN mat improved the osteoblast cell proliferation and adhesion. The aim of this study is to develop a novel functional composite nanofiber (FCN) loaded beta-tricalcium phosphate (β-TCP) and simvastatin (SIM) FCN mat for bone tissue regeneration. The advantage of electrospinning technique was considered for the uniform distribution of β-TCP and SIM drug. In vitro drug release study performed in phosphate buffer solution (PBS) showed the controlled and sustained release of SIM, and the Kopcha model was used to investigate the drug release mechanism. The morphology of the electrospun nanofibers was investigated using field-emission scanning electron microscopy (FE-SEM). Assessment of the in vitro bioactivity of the nanofibers was carried out in simulated body fluid (SBF). FE-SEM and EDS analysis confirmed the formation of an apatite-like layer. Moreover, in vitro studies revealed that the FCN mat displayed better cell proliferation and adhesion than merely control fiber. This suggests versatile applications of the fabricated FCN mat for control drug delivery and bone tissue regeneration application.