Calcitonin Gene‐Related Peptide Receptor Antagonists (Gepants) for the Acute Treatment of Nausea in Episodic Migraine: A Systematic Review and Meta‐Analysis

• Published in: Headache Vol. 60; no. 7; pp. 1489 - 1499
• Main Authors: Chan, Tommy Lik Hang, Cowan, Robert P., Woldeamanuel, Yohannes W.
• Format: Journal Article
• Language: English
• Published: Mt. Royal Wiley Subscription Services, Inc 01.07.2020
• Subjects: Accumulation; Age; Bias; Bibliographic data bases; Calcitonin; calcitonin gene‐related peptide; CGRP receptor antagonists; Clinical trials; Data analysis; gepants; Headache; Heterogeneity; Identification methods; Meta-analysis; Migraine; Nausea; Outliers (statistics); Patients; Peptides; Receptors; Regression analysis; Sensitivity analysis; Sex ratio; Vomiting

Objective To synthesize the evidence on the efficacy of calcitonin gene‐related peptide receptor antagonists (gepants) from all clinical trials addressing nausea treatment for episodic migraine. Introduction Nausea is one of the most bothersome symptoms in patients with migraine. The most bothersome...