Molecular Mechanisms Driving mRNA Degradation by m6A Modification

• Published in: Trends in genetics Vol. 36; no. 3; pp. 177 - 188
• Main Authors: Lee, Yujin, Choe, Junho, Park, Ok Hyun, Kim, Yoon Ki
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.03.2020
• Subjects: circular RNA; endoribonucleolytic cleavage; HRSP12; m6A modification; RNase P/MRP; YTHDF2; m6A modification; YTHDF2; RNase P/MRP; circular RNA; endoribonucleolytic cleavage; HRSP12

N6-Methyladenosine (m6A), the most prevalent internal modification associated with eukaryotic mRNAs, influences many steps of mRNA metabolism, including splicing, export, and translation, as well as stability. Recent studies have revealed that m6A-containing mRNAs undergo one of two distinct pathway...