Targeting of the IGFBP3/TMEM219 pathway restores intestinal stem cells capability of healing mucosa in gastrointestinal autoimmune disorders

• Published in: Pharmacological research Vol. 219; p. 107901
• Main Authors: Amabile, Giovanni, D’Addio, Francesca, Maestroni, Anna, Zangarini, Monique, Porzio, Stefano, Camboni, Maria Gabriella, Assi, Emma, Petrazzuolo, Adriana, Loretelli, Cristian, Ben Nasr, Moufida, Usuelli, Vera, Abdelsalam, Ahmed, Seelam, Andy Joe, Zocchi, Monica, Corradi, Domenico, Marin, Virna, Bruckmann, Chiara, Nardini, Marta, Canducci, Filippo, Nardini, Claudia, Danese, Silvio, Zuccotti, Gianvincenzo, Sampietro, Gianluca M., Ardizzone, Sandro, Fiorina, Paolo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2025; Elsevier
• Subjects: IGFBP3; Intestinal organoids; Monoclonal antibodies; TMEM219; Monoclonal antibodies; TMEM219; IGFBP3; Intestinal organoids

Insulin-like growth factor binding protein 3 (IGFBP3) signals through the death receptor TMEM219 to modulate survival of target cells; inhibition of this signaling has been associated with a rescue of intestinal stem cell death. Here we report the screening, generation, and characterization of fully...