PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti‐biofilm product
Bacterial infections have increased dramatically due to microbial biofilm formation resulting in chronic pathological conditions in human subjects. Microbial biofilm causes poor drug penetration and antibiotic resistance, which has made site‐specific sustained drug delivery the most appropriate opti...
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| Published in | Journal of applied polymer science Vol. 138; no. 18 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, USA
John Wiley & Sons, Inc
10.05.2021
Wiley Subscription Services, Inc |
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| Abstract | Bacterial infections have increased dramatically due to microbial biofilm formation resulting in chronic pathological conditions in human subjects. Microbial biofilm causes poor drug penetration and antibiotic resistance, which has made site‐specific sustained drug delivery the most appropriate option. Our work entails fabrication of ciprofloxacin hydrochloride (CPX) loaded nanofibers using polyvinyl alcohol (PVA) and poly(meth) methacrylate (PMMA) employing electrospinning method to form PVA:PMMA:CPX nanofibers mat. These nanofibers mat were optimized, characterized, and further subjected to anti‐biofilm activity. Microscopic images revealed average nanofibers diameter of 243 ± 80 nm with smooth surface morphology. Analytical graphs and thermal analysis confirmed drug encapsulation and drug‐polymer compatibility. In vitro studies demonstrated sustained release of CPX for 22 days displaying Hixon Crowell and two‐stage desorption kinetics. Anti‐biofilm activity showed zones of inhibition 3.0 ± 0.5 cm, 2.8 ± 0.1 cm, 2.9 ± 0.2 cm for Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, respectively which was well above the minimum inhibitory concentration levels of the bacteria forming biofilm. Conclusively, these nanofibers mat have potential to be used as an anti‐biofilm product. |
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| AbstractList | Bacterial infections have increased dramatically due to microbial biofilm formation resulting in chronic pathological conditions in human subjects. Microbial biofilm causes poor drug penetration and antibiotic resistance, which has made site‐specific sustained drug delivery the most appropriate option. Our work entails fabrication of ciprofloxacin hydrochloride (CPX) loaded nanofibers using polyvinyl alcohol (PVA) and poly(meth) methacrylate (PMMA) employing electrospinning method to form PVA:PMMA:CPX nanofibers mat. These nanofibers mat were optimized, characterized, and further subjected to anti‐biofilm activity. Microscopic images revealed average nanofibers diameter of 243 ± 80 nm with smooth surface morphology. Analytical graphs and thermal analysis confirmed drug encapsulation and drug‐polymer compatibility. In vitro studies demonstrated sustained release of CPX for 22 days displaying Hixon Crowell and two‐stage desorption kinetics. Anti‐biofilm activity showed zones of inhibition 3.0 ± 0.5 cm, 2.8 ± 0.1 cm, 2.9 ± 0.2 cm for Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, respectively which was well above the minimum inhibitory concentration levels of the bacteria forming biofilm. Conclusively, these nanofibers mat have potential to be used as an anti‐biofilm product. Bacterial infections have increased dramatically due to microbial biofilm formation resulting in chronic pathological conditions in human subjects. Microbial biofilm causes poor drug penetration and antibiotic resistance, which has made site‐specific sustained drug delivery the most appropriate option. Our work entails fabrication of ciprofloxacin hydrochloride (CPX) loaded nanofibers using polyvinyl alcohol (PVA) and poly(meth) methacrylate (PMMA) employing electrospinning method to form PVA:PMMA:CPX nanofibers mat. These nanofibers mat were optimized, characterized, and further subjected to anti‐biofilm activity. Microscopic images revealed average nanofibers diameter of 243 ± 80 nm with smooth surface morphology. Analytical graphs and thermal analysis confirmed drug encapsulation and drug‐polymer compatibility. In vitro studies demonstrated sustained release of CPX for 22 days displaying Hixon Crowell and two‐stage desorption kinetics. Anti‐biofilm activity showed zones of inhibition 3.0 ± 0.5 cm, 2.8 ± 0.1 cm, 2.9 ± 0.2 cm for Escherichia coli , Staphylococcus aureus , Enterococcus faecalis , respectively which was well above the minimum inhibitory concentration levels of the bacteria forming biofilm. Conclusively, these nanofibers mat have potential to be used as an anti‐biofilm product. |
| Author | Chauhan, Deepika Das, Ayan K. Iqbal, Zeenat Solanki, Pratima R. Singh, Manvi |
| Author_xml | – sequence: 1 givenname: Manvi orcidid: 0000-0002-9869-8077 surname: Singh fullname: Singh, Manvi organization: School of Pharmaceutical Education and Research, Jamia Hamdard – sequence: 2 givenname: Deepika orcidid: 0000-0002-1129-6578 surname: Chauhan fullname: Chauhan, Deepika organization: Jawaharlal Nehru University – sequence: 3 givenname: Ayan K. orcidid: 0000-0001-9451-2434 surname: Das fullname: Das, Ayan K. organization: Hamdard Institute of Medical Sciences and Research, Jamia Hamdard – sequence: 4 givenname: Zeenat orcidid: 0000-0002-2798-0390 surname: Iqbal fullname: Iqbal, Zeenat email: zeenatiqbal@jamiahamdard.ac.in organization: School of Pharmaceutical Education and Research, Jamia Hamdard – sequence: 5 givenname: Pratima R. orcidid: 0000-0003-1679-2180 surname: Solanki fullname: Solanki, Pratima R. email: partima@mail.jnu.ac.in, partimarsolanki@gmail.com organization: Jawaharlal Nehru University |
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| SubjectTerms | Antibiotics Bacterial diseases biofilm Biofilms drug delivery systems E coli electrospinning Materials science Microorganisms Morphology Nanofibers Penetration resistance Polymers Polymethyl methacrylate Polyvinyl alcohol Sustained release Thermal analysis |
| Title | PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti‐biofilm product |
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