Electrospinning and crosslinking of polyvinyl alcohol/chitosan composite nanofiber for transdermal drug delivery

• Published in: Advances in polymer technology Vol. 37; no. 6; pp. 1917 - 1928
• Main Authors: Cui, Zhixiang, Zheng, Zifeng, Lin, Luyin, Si, Junhui, Wang, Qianting, Peng, Xiangfang, Chen, Wenzhe
• Format: Journal Article
• Language: English
• Published: London John Wiley & Sons, Inc 01.10.2018
• Subjects: Ampicillin; Chitosan; chitosan (CS); Crosslinking; drug delivery; Drug delivery systems; Electrospinning; Hydrophobicity; Mechanical properties; Modulus of elasticity; Morphology; Nanofibers; Organic chemistry; Polyvinyl alcohol; polyvinyl alcohol (PVA); Thermodynamic properties; Transdermal medication

The drug‐loaded polyvinyl alcohol (PVA)/chitosan (CS) composite nanofibers intended to be used as matrix for transdermal drug delivery were fabricated by electrospinning, and then crosslinked through glulataraldehyde (GA). The morphology, chemical structure, thermal behavior, mechanical properties,...