The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis

• Published in: Critical reviews in oncogenesis Vol. 16; no. 1-2; p. 65
• Main Author: Eklund, Elizabeth
• Format: Journal Article
• Language: English
• Published: United States 2011
• Subjects: Animals; Cell Transformation, Neoplastic; Gene Expression Regulation; Hematopoiesis - physiology; Homeodomain Proteins - genetics; Homeodomain Proteins - physiology; Humans; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - physiopathology; Mice; Prognosis; Transcription Factors - physiology; Translocation, Genetic

Acute myeloid leukemia (AML) is a heterogeneous disease with highly variable prognoses. Identification of recurring chromosomal translocations provides some prognostic information for individual AML subjects. Population based gene-expression profiling studies also identified abnormalities relevant t...