Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis

• Published in: Thrombosis and haemostasis Vol. 119; no. 11; p. 1827
• Main Authors: Drost, Carolin Christina, Rovas, Alexandros, Kusche-Vihrog, Kristina, Van Slyke, Paul, Kim, Harold, Hoang, Van C, Maynes, Jason T, Wennmann, Dirk Oliver, Pavenstädt, Hermann, Linke, Wolfgang, Lukasz, Alexander, Hesse, Bettina, Kümpers, Philipp
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2019
• Subjects: Adult; Aged; Angiopoietin-2 - blood; Case-Control Studies; Cell Line; Endothelial Cells - metabolism; Endothelial Cells - pathology; Female; Glucuronidase - metabolism; Glycocalyx - metabolism; Glycocalyx - pathology; Heparitin Sulfate - metabolism; Humans; Intravital Microscopy; Male; Microscopy, Atomic Force; Middle Aged; Phosphorylation; Prospective Studies; Receptor, TIE-2 - metabolism; Sepsis - blood; Sepsis - metabolism; Sepsis - pathology; Signal Transduction
• ISSN: 2567-689X
• DOI: 10.1055/s-0039-1695768

The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rap...