Active site geometry of porcine pancreatic lipase: An interesting switchover from Jones' to Seebach's model
Porcine pancreatic lipase (PPL)-catalyzed hydrolysis of cis 3-acetoxyethyl-1,4-diphenyl and cis 3-acetoxyethyl-1-phenyl-4-(2-furyl) beta-lactams 1a and 1b proceeded with opposite stereoselectivity while the corresponding thienyl beta-lactam 1c showed no selectivity at all. An explanation based upon...
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Published in | Bioorganic & medicinal chemistry letters Vol. 11; no. 3; pp. 305 - 307 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier
12.02.2001
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Subjects | |
Online Access | Get full text |
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