Essential oil of Syzygium aromaticum reverses the deficits of stress-induced behaviors and hippocampal p-ERK/p-CREB/brain-derived neurotrophic factor expression

• Published in: Planta medica Vol. 81; no. 3; p. 185
• Main Authors: Liu, Bin-Bin, Luo, Liu, Liu, Xiao-Long, Geng, Di, Li, Cheng-Fu, Chen, Shao-Mei, Chen, Xue-Mei, Yi, Li-Tao, Liu, Qing
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2015
• Subjects: Animals; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Brain-Derived Neurotrophic Factor - metabolism; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Food Preferences; Hindlimb Suspension; Hippocampus - metabolism; Male; Mice, Inbred ICR; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Oils, Volatile - therapeutic use; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats, Sprague-Dawley; Stress, Psychological - drug therapy; Sucrose - administration & dosage; Swimming; Syzygium - chemistry

Syzygium aromaticum has been widely used in traditional medicine. Our study investigated the safety and antidepressant-like effects of the essential oil of S. aromaticum after acute or long-term treatment. Using GC-MS, a total of eight volatile constituents were identified in the essential oil of S....