Mechanistic Insights and Anti-cancer Activity of 2H-benzo[b][1,4]oxazin-3(4H)-one Linked 1,2,3-Triazoles in Human Cancer Cells

• Published in: Frontiers in pharmacology Vol. 16; p. 1565657
• Main Authors: Liu, Qingying, Hou, Xixi, Tian, Mingyue, He, Baoyu, Guo, Jingjing, Guo, Yajie, Yang, Jianxue
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.06.2025
• Subjects: 1, 2, 3-triazole; 2H-benzo[b][1,4]oxazin-3(4H)-one; anticancer; apoptosis; DNA damage; ROS; 2H-benzo[b][1,4]oxazin-3(4H)-one; apoptosis; 1, 2, 3-triazole; DNA damage; anticancer; ROS

A series of 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives linked to 1,2,3-triazoles were designed, synthesized, and evaluated for their anticancer activity in several human cancer cell lines, including A549 (lung), Huh7 (liver), MCF-7 (breast), HCT-116 (colon), and SKOV3 (ovary). Cell viability assa...