A sensitive UPLC-MS/MS method for simultaneous quantification of one-carbon metabolites & co-factors in human plasma

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 219; p. 114944
• Main Authors: Chen, Ping, Tang, Yun, He, Qiangqiang, Liu, Lishun, Zhou, Ziyi, Song, Yun, Zhang, Nan, Wang, Binyan, Zhou, Houqing, Shi, Hanping, Jiang, Jie
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 20.09.2022
• Subjects: Folic acid; Homocysteine; Human plasma; LC-MS/MS; One-carbon metabolism; LC-MS/MS; One-carbon metabolism; Human plasma; Homocysteine; Folic acid

One-carbon metabolism is an important metabolic pathway involved in many diseases, such as congenital malformations, tumours, cardiovascular diseases, anaemia, depression, cognitive diseases and liver disease. However, the current methods have specific defects in detecting and qualifying the related...