Investigation of imaging the somatostatin receptor by opening the blood-brain barrier with melittin – A feasibility study using positron emission tomography and [64Cu]Cu-DOTATATE

• Published in: Nuclear medicine and biology Vol. 132-133; p. 108905
• Main Authors: Andersen, Ida Vang, Bidesi, Natasha Shalina Rajani, Shalgunov, Vladimir, Jørgensen, Jesper Tranekjær, Gustavsson, Tobias, Strømgaard, Kristian, Ingemann Jensen, Andreas T., Kjær, Andreas, Herth, Matthias M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2024
• Subjects: 64Cu; Autoradiography; BBB; Biodistribution; Blood-brain barrier; DOTATATE; Melittin; PET; Somatostatin; SSTR; Autoradiography; Melittin; BBB; Blood-brain barrier; DOTATATE; SSTR; 64Cu; Somatostatin; Biodistribution; PET; Cu

DOTATATE is a somatostatin peptide analog used in the clinic to detect somatostatin receptors which are highly expressed on neuroendocrine tumors. Somatostatin receptors are found naturally in the intestines, pancreas, lungs, and brain (mainly cortex). In vivo measurement of the somatostatin recepto...