Fibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications

• Published in: Seminars in thrombosis and hemostasis
• Main Authors: Rashedi, Sina, Greason, Christie M, Sadeghipour, Parham, Talasaz, Azita H, O'Donoghue, Michelle L, Jimenez, David, Monreal, Manuel, Anderson, Christopher D, Elkind, Mitchell S V, Kreuziger, Lisa M Baumann, Lang, Irene M, Goldhaber, Samuel Z, Konstantinides, Stavros V, Piazza, Gregory, Krumholz, Harlan M, Braunwald, Eugene, Bikdeli, Behnood
• Format: Journal Article
• Language: English
• Published: United States 01.03.2024

Fibrinolytic agents catalyze the conversion of the inactive proenzyme plasminogen into the active protease plasmin, degrading fibrin within the thrombus and recanalizing occluded vessels. The history of these medications dates to the discovery of the first fibrinolytic compound, streptokinase, from...