Cerebral acid-base homeostasis after severe traumatic brain injury

• Published in: Journal of neurosurgery Vol. 103; no. 4; p. 597
• Main Authors: Clausen, Tobias, Khaldi, Ahmad, Zauner, Alois, Reinert, Michael, Doppenberg, Egon, Menzel, Matthias, Soukup, Jens, Alves, Oscar Luis, Bullock, M Ross
• Format: Journal Article
• Language: English
• Published: United States 01.10.2005
• Subjects: Acid-Base Equilibrium - physiology; Adult; Brain Chemistry; Brain Injuries - complications; Carbon Dioxide - analysis; Cell Death; Female; Homeostasis; Humans; Hydrogen-Ion Concentration; Lactic Acid - analysis; Male; Middle Aged

Brain tissue acidosis is known to mediate neuronal death. Therefore the authors measured the main parameters of cerebral acid-base homeostasis, as well as their interrelations, shortly after severe traumatic brain injury (TBI) in humans. Brain tissue pH, PCO2, PO2, and/or lactate were measured in 15...