The coronary sinus reducer: clinical evidence and technical aspects

• Published in: Expert review of cardiovascular therapy Vol. 15; no. 1; p. 47
• Main Authors: Giannini, Francesco, Aurelio, Andrea, Jabbour, Richard J, Ferri, Luca, Colombo, Antonio, Latib, Azeem
• Format: Journal Article
• Language: English
• Published: England 02.01.2017
• Subjects: Angina, Stable - diagnosis; Angina, Stable - physiopathology; Angina, Stable - psychology; Angina, Stable - surgery; Catheterization, Central Venous - adverse effects; Catheterization, Central Venous - instrumentation; Catheterization, Central Venous - methods; Central Venous Catheters; Coronary Sinus - diagnostic imaging; Coronary Sinus - physiopathology; Coronary Sinus - surgery; Humans; Pain, Intractable - physiopathology; Pain, Intractable - psychology; Pain, Intractable - surgery; Prosthesis Design; Prosthesis Fitting - methods; Quality of Life; Treatment Outcome; coronary artery disease; refractory angina; myocardial ischemia; angina pectoris; Coronary sinus reducer implantation
• ISSN: 1744-8344
• DOI: 10.1080/14779072.2017.1270755

Chronic refractory angina is often a disabling condition, predominantly due to severe obstructive coronary artery disease, that is inadequately controlled by optimal medical therapy and not amenable to further percutaneous or surgical revascularization. mortality rates associated with this condition are relatively low in clinically stable patients. however, it is associated with a high hospitalization rate and a reduction in both exercise capacity and quality of life. due to the paucity of available treatment options, there is an unmet need for new therapies for these patients and for a reduction in the associated economic healthcare burden. Areas covered: This review is focusing on the clinical evidence and technical aspects of this new therapeutic modality in refractory angina patients unsuitable for revascularization. Expert commentary: The Coronary Sinus Reducer (Neovasc Inc. Richmond B.C., Canada) is a new percutaneous device designed to achieve a controlled narrowing of the coronary sinus that may alleviate myocardial ischemia, possibly by redistributing blood from the less ischemic sub-epicardium to the more ischemic sub-endocardium, or by neoangiogenesis. Recently, a randomized, double-blind, multi-center clinical trial demonstrated a benefit in improving symptoms in 104 refractory angina patients, when compared to placebo.