Hematopoietic stem cells give rise to perivascular endothelial-like cells during brain tumor angiogenesis

• Published in: Stem cells and development Vol. 14; no. 5; p. 478
• Main Authors: Udani, V M, Santarelli, J G, Yung, Y C, Wagers, A J, Cheshier, S H, Weissman, I L, Tse, V
• Format: Journal Article
• Language: English
• Published: United States 01.10.2005
• Subjects: Animals; Antigens - metabolism; Antigens, CD34 - metabolism; Biomarkers - metabolism; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Endothelial Cells - cytology; Endothelial Cells - metabolism; Endothelium, Vascular - cytology; Green Fluorescent Proteins - metabolism; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - physiology; Humans; Leukocyte Common Antigens - metabolism; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Rats; Transplantation Chimera; von Willebrand Factor - immunology

Bone marrow (BM) cells have recently been shown to give rise to skeletal, hepatic, cardiac, neural, and vascular endothelial tissues. However, it has been shown that this is the result of cell fusion rather than transdifferentiation of hematopoietic stem cells (HSC). For this study, we established a...