DAla2GIP antagonizes H2O2-induced chondrocyte apoptosis and inflammatory factor secretion

• Published in: Bone (New York, N.Y.) Vol. 127; pp. 656 - 663
• Main Authors: Wang, Yuze, Xiang, Chuan, Sun, Xiaojuan, Wu, Song, Lv, Jia, Li, Pengcui, Wei, Xiaochun, Wei, Lei
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2019
• Subjects: Chondrocyte apoptosis; Inflammatory factor; Non-invasive calcium detection; Osteoarthritis (OA); PI3K/Akt/NF-κB pathway; Osteoarthritis (OA); Chondrocyte apoptosis; PI3K/Akt/NF-κB pathway; Non-invasive calcium detection; Inflammatory factor

To investigate the protective effects of DAla2GIP against the apoptosis and inflammatory factor secretion in H2O2-induced chondrocyte, and explore the possible mechanisms of DAla2GIP underlying its protection. The chondrocytes were divided into the following four groups: Control, 300 μM H2O2, 100 pM...