Effects of L-Arginine on 7-Nitroindazole-Induced Reference and Working Memory Performance of Rats

• Published in: Pharmacology Vol. 84; no. 4; pp. 211 - 218
• Main Authors: Akar, Füruzan Yildiz, Celikyurt, Ipek Komsuoglu, Ulak, Guner, Mutlu, Oguz
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2009
• Subjects: Animals; Arginine - pharmacology; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors - pharmacology; Indazoles - antagonists & inhibitors; Indazoles - pharmacology; Male; Memory - drug effects; Original Paper; Rats; Rats, Wistar; Reference memory; 7-Nitroindazole; Working memory; Nitric oxide; Three-panel runway test

Background/Aims: This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. Methods: 7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min b...