Update: the role of epigenetics in the metabolic memory of diabetic complications

• Published in: American journal of physiology. Renal physiology Vol. 327; no. 3; pp. F327 - F339
• Main Authors: Chen, Zhuo, Malek, Vajir, Natarajan, Rama
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2024
• Subjects: Animal models; Animals; Chromatin; Clinical trials; Diabetes; Diabetes Complications - genetics; Diabetes Complications - metabolism; Diabetes mellitus; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; DNA Methylation; DNA structure; Environmental factors; Epigenesis, Genetic; Epigenetics; Genetic factors; Genomic analysis; Histones; Humans; Hyperglycemia; Hyperlipidemia; Kidney diseases; Metabolism; Morbidity; Nucleotide sequence; Overnutrition; diabetic complications; diabetic kidney disease; epigenetic modifications; metabolic memory; epigenetics

Diabetes, a chronic disease characterized by hyperglycemia, is associated with significantly accelerated complications, including diabetic kidney disease (DKD), which increases morbidity and mortality. Hyperglycemia and other diabetes-related environmental factors such as overnutrition, sedentary li...