Asymptomatic Deep Vein Thrombosis is Associated with an Increased Risk of Death: Insights from the APEX Trial

• Published in: Thrombosis and haemostasis Vol. 118; no. 12; p. 2046
• Main Authors: Kalayci, Arzu, Gibson, C Michael, Chi, Gerald, Yee, Megan K, Korjian, Serge, Datta, Sudarshana, Nafee, Tarek, Gurin, Mike, Haroian, Noah, Qamar, Iqra, Hull, Russell D, Hernandez, Adrian F, Cohen, Alexander T, Harrington, Robert A, Goldhaber, Samuel Z
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2018
• Subjects: Aged; Aged, 80 and over; Anticoagulants - therapeutic use; Asymptomatic Diseases; Benzamides - therapeutic use; Enoxaparin - therapeutic use; Female; Humans; Male; Proportional Hazards Models; Pyridines - therapeutic use; Risk; Survival Analysis; United States - epidemiology; Venous Thromboembolism - drug therapy; Venous Thromboembolism - epidemiology; Venous Thromboembolism - mortality; Venous Thrombosis - drug therapy; Venous Thrombosis - epidemiology; Venous Thrombosis - mortality; United States

Asymptomatic deep vein thrombosis (DVT) diagnosed with compression ultrasound (CUS) is a common endpoint in trials assessing the efficacy of anticoagulants to prevent venous thromboembolism (VTE), but the relationship of asymptomatic thrombus to mortality remains uncertain.  In the APEX trial (Clini...