Reply to Comment on: Visual Visual Impairment in Fungal Versus Bacterial Corneal Ulcers 4 Years After Successful Antimicrobial Treatment

• Published in: American journal of ophthalmology Vol. 210; pp. 196 - 197
• Main Authors: Prajna, Namperumalsamy V., Srinivasan, Muthiah, Lietman, Thomas M., Keenan, Jeremy D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2020; Elsevier Limited
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents; Conflicts of interest; Cornea; Corneal Ulcer; Eye Infections, Bacterial; Humans; Ulcers; Vision Disorders; Visual impairment; New York; San Francisco California; United States > US; India; South Asia
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2019.10.001

[...]we agree that further research on this topic is needed. Funding/Support: The research was supported by US National Institutes of Health/National Eye Institute (Bethesda, MD) grants (U10EY015114, K23EY019071, and P30EY002162); and by That Man May See (San Francisco, CA), the South Asia Research Fund (San Francisco, CA), and Research to Prevent Blindness (New York, NY). Enrollment Characteristic Odds Ratio (95% Confidence Interval)a Presenting Vision Worse Than 20/400b BSCVA Worse Than 20/400 CLVA Worse Than 20/400 Fungal (vs bacterial) 13.2 (1.69-102.5)c 8.08 (1.06-61.6)d 16.7 (1.64-169.6)e Symptom duration, per day 1.04 (0.92-1.17) 1.03 (0.92-1.17) 1.00 (0.87-1.47) Visual acuity, per line 1.25 (1.11-1.63) 1.23 (1.02-1.49) 1.25 (1.03-1.51) Infiltrate size, per mmf 2.39 (1.27-4.50) 2.65 (1.40-5.00) 2.76 (1.43-5.33) Infiltrate depth Anterior third Reference Reference Reference Middle third 1.44 (0.26-8.01) 1.68 (0.29-9.69) 1.38 (0.23-8.28) Posterior third 1.81 (0.23-14.3) 1.97 (0.25-15.7) 2.52 (0.30-21.4) Infiltrate in central 4 mmg 0.05 (0.01-0.56) 0.09 (0.01-0.88) 0.05 (0.004-0.64) Hypopyon present 0.68 (0.12-3.94) 1.20 (0.21-6.96) 1.21 (0.20-7.21) Table Predictors of Blindness in a Sample of Bacterial and Fungal Corneal Ulcers Four Years Following Diagnosis and Treatment