Alzheimer’s disease, Huntington’s disease and cancer
•Inverse relationship may exist between neurodegenerative disorders and cancer.•There exists a reduced cancer incidence in Alzheimer’s disease, but not in Huntington’s disease.•This finding hints at different molecular mechanisms between these disorders. Neurodegenerative disorders and cancer are tw...
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Published in | Journal of clinical neuroscience Vol. 93; pp. 103 - 105 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.11.2021
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Abstract | •Inverse relationship may exist between neurodegenerative disorders and cancer.•There exists a reduced cancer incidence in Alzheimer’s disease, but not in Huntington’s disease.•This finding hints at different molecular mechanisms between these disorders.
Neurodegenerative disorders and cancer are two of the most common groups of conditions in our world. Some studies have proposed that neurodegenerative disorders may be protective of the development of cancer.
We tested this hypothesis using two neurodegenerative disorders with different molecular pathophysiology – Alzheimer’s disease (AD) and Huntington’s disease (HD) – to see if the inverse relationship between cancer and neurodegeneration was generalizable. Five-year cancer incidence was determined in two large datasets: AD using the C-Path Online Date Repository (CODR) database (n = 6383) and HD using the ENROLL-HD database (n = 2608). Cancer incidence was determined in the populations and compared to normal population data for Australia, United Kingdom and the United States of America. Age-sex standardized rates of cancer were determined and expressed as 95% confidence intervals. We describe an age-sex standardized cancer rate of 1179.6/per 100,000 population to 1253.7/per 100,000 population in normal populations.
The rate in AD was 815.2/per 100,000 population (95% CI 813.32–817.5/per 100,000 population) and for HD 1296.6/per 100,000 population (95% CI 1288–1308.2/per 100,000 population).
We conclude that patients with AD have a reduced age-sex standardized rate of developing cancer not shared with HD, a finding that hints at different molecular mechanisms. |
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AbstractList | •Inverse relationship may exist between neurodegenerative disorders and cancer.•There exists a reduced cancer incidence in Alzheimer’s disease, but not in Huntington’s disease.•This finding hints at different molecular mechanisms between these disorders.
Neurodegenerative disorders and cancer are two of the most common groups of conditions in our world. Some studies have proposed that neurodegenerative disorders may be protective of the development of cancer.
We tested this hypothesis using two neurodegenerative disorders with different molecular pathophysiology – Alzheimer’s disease (AD) and Huntington’s disease (HD) – to see if the inverse relationship between cancer and neurodegeneration was generalizable. Five-year cancer incidence was determined in two large datasets: AD using the C-Path Online Date Repository (CODR) database (n = 6383) and HD using the ENROLL-HD database (n = 2608). Cancer incidence was determined in the populations and compared to normal population data for Australia, United Kingdom and the United States of America. Age-sex standardized rates of cancer were determined and expressed as 95% confidence intervals. We describe an age-sex standardized cancer rate of 1179.6/per 100,000 population to 1253.7/per 100,000 population in normal populations.
The rate in AD was 815.2/per 100,000 population (95% CI 813.32–817.5/per 100,000 population) and for HD 1296.6/per 100,000 population (95% CI 1288–1308.2/per 100,000 population).
We conclude that patients with AD have a reduced age-sex standardized rate of developing cancer not shared with HD, a finding that hints at different molecular mechanisms. |
Author | Panegyres, Peter K. Chen, Huei-Yang |
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Cites_doi | 10.1212/01.WNL.0000152889.94785.51 10.1136/bmj.e1442 10.2174/0929867326666190716130150 10.1016/S1470-2045(11)70041-9 10.1002/mdc3.12388 10.3233/JAD-151089 10.1007/s10522-014-9523-2 10.1007/s10522-012-9403-6 10.1212/WNL.0b013e3181c91873 10.1002/(SICI)1097-0142(19991001)86:7<1342::AID-CNCR33>3.0.CO;2-3 10.1016/S1470-2045(12)70132-8 10.1098/rsif.2013.0006 10.1371/journal.pgen.1001257 10.1212/WNL.0b013e31829c5ec1 10.1093/aje/kwt232 |
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References | McNulty, Pilcher, Ramesh, Necuiniate, Hughes, Farewell (b0050) 2018; 7 Sorensen SA, Fenger K, Olsen JH. Significantly lower incidence of cancer among patients with Huntington disease: an apoptotic effect of an expanded polyglutamine tract. Cancer 1999; 86: 1342–6. Landwehrmeyer, Fitzer-Attas, Giuliano, Gonçalves, Anderson, Cardoso (b0060) 2017; 4 Plun-Favreau H, Lewis PA, Hardy J, Martins LM, Wood NW. Cancer and neurodegeneration: between the devil and the deep blue sea. PLOS Genet 2010; 6(12): e1001257. DOI: 10.1371/journal.pgen.1001257. Roe, Fitzpatrick, Xiong, Sieh, Kuller, Miller (b0025) 2010; 74 Musicco, Adorni, Di Santo, Prinelli, Pettenati, Caltagirone (b0035) 2013; 81 Driver (b0075) 2014; 15 Ji, Sundquist, Sundquist (b0045) 2012; 13 Tabarés-Seisdedos, Dumont, Baudot, Valderas, Climent, Valencia (b0010) 2011; 12 Wirdefeldt, Weibull, Chen, Kamel, Lundholm, Fang (b0015) 2014; 179 Szczechowiak, Brzecka, Hachiya, Wyka, Leszek (b0080) 2019 Ospina-Romero, Abdiwahab, Kobayashi, Filshtein, Brenowitz, Mayeda (b0085) 2019; 2 Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, et al. Inverse association between cancer and Alzheimer’s disease: results from the Framingham Heart Study. BMJ 2012; 344: e1442. Chen, Panegyres (b0055) 2016; 51 Roe, Behrens, Xiong, Miller, Morris (b0020) 2005; 64 Demetrius, Simon (b0065) 2012; 13 Demetrius, Simon (b0070) 2013; 10 Musicco (10.1016/j.jocn.2021.09.012_b0035) 2013; 81 Szczechowiak (10.1016/j.jocn.2021.09.012_b0080) 2019 McNulty (10.1016/j.jocn.2021.09.012_b0050) 2018; 7 Demetrius (10.1016/j.jocn.2021.09.012_b0070) 2013; 10 Ospina-Romero (10.1016/j.jocn.2021.09.012_b0085) 2019; 2 10.1016/j.jocn.2021.09.012_b0005 Roe (10.1016/j.jocn.2021.09.012_b0025) 2010; 74 Landwehrmeyer (10.1016/j.jocn.2021.09.012_b0060) 2017; 4 Wirdefeldt (10.1016/j.jocn.2021.09.012_b0015) 2014; 179 10.1016/j.jocn.2021.09.012_b0030 10.1016/j.jocn.2021.09.012_b0040 Demetrius (10.1016/j.jocn.2021.09.012_b0065) 2012; 13 Tabarés-Seisdedos (10.1016/j.jocn.2021.09.012_b0010) 2011; 12 Roe (10.1016/j.jocn.2021.09.012_b0020) 2005; 64 Ji (10.1016/j.jocn.2021.09.012_b0045) 2012; 13 Driver (10.1016/j.jocn.2021.09.012_b0075) 2014; 15 Chen (10.1016/j.jocn.2021.09.012_b0055) 2016; 51 |
References_xml | – volume: 74 start-page: 106 year: 2010 end-page: 112 ident: b0025 article-title: Cancer linked to Alzheimer disease but not vascular dementia publication-title: Neurology contributor: fullname: Miller – volume: 2 start-page: e196160 year: 2019 ident: b0085 article-title: Rate of memory change before and after cancer diagnosis publication-title: JAMA contributor: fullname: Mayeda – volume: 81 start-page: 322 year: 2013 end-page: 328 ident: b0035 article-title: Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study publication-title: Neurology contributor: fullname: Caltagirone – volume: 4 start-page: 212 year: 2017 end-page: 224 ident: b0060 article-title: Data analytics from enroll-HD, a global clinical research platform for Huntington's disease publication-title: Mov Disord Clin Pract contributor: fullname: Cardoso – year: 2019 ident: b0080 article-title: Association between Alzheimer’s disease and cancer: a short overview publication-title: Curr Med Chem contributor: fullname: Leszek – volume: 179 start-page: 85 year: 2014 end-page: 94 ident: b0015 article-title: Parkinson’s disease and cancer: a register-based family study publication-title: Am J Epidemiol contributor: fullname: Fang – volume: 13 start-page: 642 year: 2012 end-page: 648 ident: b0045 article-title: Cancer incidence in patients with polyglutamine diseases: a population-based study in Sweden publication-title: Lancet Oncol contributor: fullname: Sundquist – volume: 10 start-page: 20130006 year: 2013 ident: b0070 article-title: The inverse association of cancer and Alzheimer’s: a bioenergetic mechanism publication-title: J R Soc Interface contributor: fullname: Simon – volume: 51 start-page: 515 year: 2016 end-page: 523 ident: b0055 article-title: The role of ethnicity in Alzheimer’s disease: findings from the C-PATH online data repository publication-title: J Alzheimers Dis contributor: fullname: Panegyres – volume: 15 start-page: 547 year: 2014 end-page: 557 ident: b0075 article-title: Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence publication-title: Biogerantology contributor: fullname: Driver – volume: 7 start-page: 209 year: 2018 end-page: 222 ident: b0050 article-title: Reduced cancer incidence in Huntington’s disease: analysis in the Registry Study publication-title: J Huntingtons Dis contributor: fullname: Farewell – volume: 64 start-page: 895 year: 2005 end-page: 898 ident: b0020 article-title: Alzheimer disease and cancer publication-title: Neurology contributor: fullname: Morris – volume: 12 start-page: 604 year: 2011 end-page: 608 ident: b0010 article-title: No paradox, no progress: inverse cancer comorbidity in people with other complex diseases publication-title: Lancet Oncol contributor: fullname: Valencia – volume: 13 start-page: 583 year: 2012 end-page: 594 ident: b0065 article-title: An inverse-Warburg effect and the origin of Alzheimer’s disease publication-title: Biogerontology contributor: fullname: Simon – volume: 64 start-page: 895 issue: 5 year: 2005 ident: 10.1016/j.jocn.2021.09.012_b0020 article-title: Alzheimer disease and cancer publication-title: Neurology doi: 10.1212/01.WNL.0000152889.94785.51 contributor: fullname: Roe – ident: 10.1016/j.jocn.2021.09.012_b0030 doi: 10.1136/bmj.e1442 – year: 2019 ident: 10.1016/j.jocn.2021.09.012_b0080 article-title: Association between Alzheimer’s disease and cancer: a short overview publication-title: Curr Med Chem doi: 10.2174/0929867326666190716130150 contributor: fullname: Szczechowiak – volume: 12 start-page: 604 issue: 6 year: 2011 ident: 10.1016/j.jocn.2021.09.012_b0010 article-title: No paradox, no progress: inverse cancer comorbidity in people with other complex diseases publication-title: Lancet Oncol doi: 10.1016/S1470-2045(11)70041-9 contributor: fullname: Tabarés-Seisdedos – volume: 4 start-page: 212 year: 2017 ident: 10.1016/j.jocn.2021.09.012_b0060 article-title: Data analytics from enroll-HD, a global clinical research platform for Huntington's disease publication-title: Mov Disord Clin Pract doi: 10.1002/mdc3.12388 contributor: fullname: Landwehrmeyer – volume: 51 start-page: 515 issue: 2 year: 2016 ident: 10.1016/j.jocn.2021.09.012_b0055 article-title: The role of ethnicity in Alzheimer’s disease: findings from the C-PATH online data repository publication-title: J Alzheimers Dis doi: 10.3233/JAD-151089 contributor: fullname: Chen – volume: 15 start-page: 547 issue: 6 year: 2014 ident: 10.1016/j.jocn.2021.09.012_b0075 article-title: Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence publication-title: Biogerantology doi: 10.1007/s10522-014-9523-2 contributor: fullname: Driver – volume: 13 start-page: 583 year: 2012 ident: 10.1016/j.jocn.2021.09.012_b0065 article-title: An inverse-Warburg effect and the origin of Alzheimer’s disease publication-title: Biogerontology doi: 10.1007/s10522-012-9403-6 contributor: fullname: Demetrius – volume: 74 start-page: 106 issue: 2 year: 2010 ident: 10.1016/j.jocn.2021.09.012_b0025 article-title: Cancer linked to Alzheimer disease but not vascular dementia publication-title: Neurology doi: 10.1212/WNL.0b013e3181c91873 contributor: fullname: Roe – ident: 10.1016/j.jocn.2021.09.012_b0040 doi: 10.1002/(SICI)1097-0142(19991001)86:7<1342::AID-CNCR33>3.0.CO;2-3 – volume: 13 start-page: 642 issue: 6 year: 2012 ident: 10.1016/j.jocn.2021.09.012_b0045 article-title: Cancer incidence in patients with polyglutamine diseases: a population-based study in Sweden publication-title: Lancet Oncol doi: 10.1016/S1470-2045(12)70132-8 contributor: fullname: Ji – volume: 2 start-page: e196160 issue: 6 year: 2019 ident: 10.1016/j.jocn.2021.09.012_b0085 article-title: Rate of memory change before and after cancer diagnosis publication-title: JAMA contributor: fullname: Ospina-Romero – volume: 7 start-page: 209 year: 2018 ident: 10.1016/j.jocn.2021.09.012_b0050 article-title: Reduced cancer incidence in Huntington’s disease: analysis in the Registry Study publication-title: J Huntingtons Dis contributor: fullname: McNulty – volume: 10 start-page: 20130006 issue: 82 year: 2013 ident: 10.1016/j.jocn.2021.09.012_b0070 article-title: The inverse association of cancer and Alzheimer’s: a bioenergetic mechanism publication-title: J R Soc Interface doi: 10.1098/rsif.2013.0006 contributor: fullname: Demetrius – ident: 10.1016/j.jocn.2021.09.012_b0005 doi: 10.1371/journal.pgen.1001257 – volume: 81 start-page: 322 issue: 4 year: 2013 ident: 10.1016/j.jocn.2021.09.012_b0035 article-title: Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study publication-title: Neurology doi: 10.1212/WNL.0b013e31829c5ec1 contributor: fullname: Musicco – volume: 179 start-page: 85 issue: 1 year: 2014 ident: 10.1016/j.jocn.2021.09.012_b0015 article-title: Parkinson’s disease 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Title | Alzheimer’s disease, Huntington’s disease and cancer |
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