Antinociceptive effect of gelsenicine, principal toxic alkaloids of gelsemium, on prostaglandin E2-induced hyperalgesia in mice: Comparison with gelsemine and koumine

• Published in: Biochemical and biophysical research communications Vol. 681; pp. 55 - 61
• Main Authors: Xu, Wen-Bo, Tang, Mo-Huan, Long, Jiang-Yu, Wang, Wei-Wei, Qin, Jiao-Yan, Qi, Xue-Jia, Liu, Zhao-Ying
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 12.11.2023
• Subjects: Gelsemine; Gelsenicine; Glycine receptor; Koumine; Pain; Gelsemine; Pain; Gelsenicine; Koumine; Glycine receptor

Gelsemium elegans (G.elegans) is a plant of the Loganiaceae family, known for its indole alkaloids, including gelsemine, koumine, and gelsenicine. Gelsemine and koumine are well-studied active alkaloids with low toxicity, valued for their anti-anxiety and analgesic properties. However, gelsenicine,...