Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves' disease with and without ophthalmopathy: correlation with clinical features

• Published in: Thyroid (New York, N.Y.) Vol. 16; no. 10; p. 967
• Main Authors: Gopinath, Bamini, Musselman, Reilly, Adams, Cherie-Lee, Tani, Junichi, Beard, Nicole, Wall, Jack R
• Format: Journal Article
• Language: English
• Published: United States 01.10.2006
• Subjects: Adult; Aged; Aged, 80 and over; Autoantibodies - blood; Calsequestrin - immunology; Cell Cycle Proteins - immunology; Collagen - immunology; Enzyme-Linked Immunosorbent Assay; Female; Flavoproteins - immunology; Graves Disease - blood; Graves Disease - drug therapy; Graves Disease - immunology; Graves Ophthalmopathy - blood; Graves Ophthalmopathy - drug therapy; Graves Ophthalmopathy - immunology; Humans; Male; Middle Aged; Oculomotor Muscles - immunology; Receptors, G-Protein-Coupled - immunology; Reference Values; Thyroxine - therapeutic use

The extraocular muscles are one of the primary tissues implicated in the autoimmune-mediated inflammation of thyroid-associated ophthalmopathy (TAO). Our aim was to determine the prevalence and level of antibodies against three candidate eye muscle antigens and the orbital fibroblast membrane antige...