Chemoenzymatic Synthesis and Anti-Inflammatory Activity of Fatty Acid Amides Prepared from Bertholletia excelsa (Brazil Nut) Triglycerides

This study reports the synthesis of fatty acid amides (FAA), analogous to anandamide, prepared from Brazil nut oil (BNO), using Amano lipase from Pseudomonas fluorescens as a catalyst of direct aminolysis, with a good yield (95-68%). The anti-inflammatory effects of BNO and FAA were evaluated by the...

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Published inJournal of the Brazilian Chemical Society Vol. 31; no. 8; pp. 1557 - 1565
Main Authors Barata, Pedro, Sarquis, Ícaro, Carvalho, Helison, Barros, Albenise, Rodrigues, Alex, Galue-Parra, Adan, Silva, Edilene, Carvalho, José Carlos, Ferreira, Irlon
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Química 01.08.2020
Subjects
CHEMISTRY, MULTIDISCIPLINARY
direct aminolysis
oleoylethanolamine
palmitoethanolamide
alkylamides
biocatalysis
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Summary:This study reports the synthesis of fatty acid amides (FAA), analogous to anandamide, prepared from Brazil nut oil (BNO), using Amano lipase from Pseudomonas fluorescens as a catalyst of direct aminolysis, with a good yield (95-68%). The anti-inflammatory effects of BNO and FAA were evaluated by the carrageenan-induced paw edema method. Analysis of the formation of edema showed that these FAA, at all dose used, significantly reduced the development of edema.
ISSN:0103-5053
1678-4790
DOI:10.21577/0103-5053.20200041