HBV induced hepatocellular carcinoma and related potential immunotherapy

[Display omitted] Chronic infection of Hepatitis B virus (HBV) has long been recognized as a major risk factor in the initiation and development of hepatocellular carcinoma (HCC), contributing to over half the cases of HCC worldwide. Transformation of the liver with HBV infection to HCC mainly resul...

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Published inPharmacological research Vol. 159; p. 104992
Main Authors Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D., Yang, Pengyuan
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.09.2020
Subjects
Hepatitis B virus (HBV)
Hepatocellular carcinoma (HCC)
Immune checkpoint inhibitors
Immunotherapy
Immune checkpoint inhibitors
Hepatitis B virus (HBV)
Immunotherapy
Hepatocellular carcinoma (HCC)
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Abstract [Display omitted] Chronic infection of Hepatitis B virus (HBV) has long been recognized as a major risk factor in the initiation and development of hepatocellular carcinoma (HCC), contributing to over half the cases of HCC worldwide. Transformation of the liver with HBV infection to HCC mainly results from long-term interaction between HBV and the host hepatocytes via a variety of mechanisms, including HBV DNA integration, prolonged expression of the viral HBx regulatory protein and/or aberrant preS/S envelope proteins, and epigenetic dysregulation of tumor suppressor genes. While there have been several failures in the development of drugs for HCC, the immune-tolerant microenvironment of this malignancy suggests that immunotherapeutic agents could provide benefits for these patients. This is supported by recent data showing that immunotherapy has promising activity in patients with advanced HCC. In this review, we provide an overview of HBV-induced HCC and recent immune based approaches for the treatment of HCC patients.
AbstractList [Display omitted] Chronic infection of Hepatitis B virus (HBV) has long been recognized as a major risk factor in the initiation and development of hepatocellular carcinoma (HCC), contributing to over half the cases of HCC worldwide. Transformation of the liver with HBV infection to HCC mainly results from long-term interaction between HBV and the host hepatocytes via a variety of mechanisms, including HBV DNA integration, prolonged expression of the viral HBx regulatory protein and/or aberrant preS/S envelope proteins, and epigenetic dysregulation of tumor suppressor genes. While there have been several failures in the development of drugs for HCC, the immune-tolerant microenvironment of this malignancy suggests that immunotherapeutic agents could provide benefits for these patients. This is supported by recent data showing that immunotherapy has promising activity in patients with advanced HCC. In this review, we provide an overview of HBV-induced HCC and recent immune based approaches for the treatment of HCC patients.
ArticleNumber 104992
Author Jia, Liyang
Gao, Yanan
He, Yaowu
Hooper, John D.
Yang, Pengyuan
Author_xml – sequence: 1
  givenname: Liyang
  surname: Jia
  fullname: Jia, Liyang
  organization: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China
– sequence: 2
  givenname: Yanan
  surname: Gao
  fullname: Gao, Yanan
  organization: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China
– sequence: 3
  givenname: Yaowu
  surname: He
  fullname: He, Yaowu
  organization: Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia
– sequence: 4
  givenname: John D.
  surname: Hooper
  fullname: Hooper, John D.
  email: john.hooper@mater.uq.edu.au
  organization: Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia
– sequence: 5
  givenname: Pengyuan
  surname: Yang
  fullname: Yang, Pengyuan
  email: pyyang@ibp.ac.cn
  organization: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China
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Hepatitis B virus (HBV)
Immunotherapy
Hepatocellular carcinoma (HCC)
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Snippet [Display omitted] Chronic infection of Hepatitis B virus (HBV) has long been recognized as a major risk factor in the initiation and development of...
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SubjectTerms Hepatitis B virus (HBV)
Hepatocellular carcinoma (HCC)
Immune checkpoint inhibitors
Immunotherapy
Title HBV induced hepatocellular carcinoma and related potential immunotherapy
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