Sustained spatiotemporal release of TGF-β1 confers enhanced very early chondrogenic differentiation during osteochondral repair in specific topographic patterns

• Published in: The FASEB journal Vol. 32; no. 10; p. 5298
• Main Authors: Asen, Ann-Kathrin, Goebel, Lars, Rey-Rico, Ana, Sohier, Jerome, Zurakowski, David, Cucchiarini, Magali, Madry, Henning
• Format: Journal Article
• Language: English
• Published: United States 01.10.2018
• Subjects: Animals; Cartilage - injuries; Cartilage - metabolism; Cartilage - physiology; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Chemokine CXCL12 - metabolism; Chondrogenesis - drug effects; Drug Implants; Endoglin - metabolism; Receptors, CXCR4 - metabolism; Swine; Swine, Miniature; Transforming Growth Factor beta - pharmacokinetics; Transforming Growth Factor beta - pharmacology; cartilage defect; cartilage repair; large animal model; scaffold

The continuous presence of TGF-β is critically important to induce effective chondrogenesis. To investigate chondrogenesis in a cartilage defect, we tested the hypothesis that the implantation of TGF-β1-releasing scaffolds improves very early cartilage repair in vivo. Spatiotemporal controlled relea...