Comparative study on hemodynamic environments around patient-specific carotid atherosclerotic plaques with different symmetrical features
Atherosclerotic plaque near the carotid sinus is a key risk factor for ischemic stroke. Although disturbed hemodynamic environments around atherosclerotic plaque had been investigated in many studies, the effect of their symmetrical features, especially longitudinal asymmetrical characteristics, had...
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| Published in | Medicine in novel technology and devices Vol. 11; p. 100079 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.09.2021
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2590-0935 2590-0935 |
| DOI | 10.1016/j.medntd.2021.100079 |
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| Abstract | Atherosclerotic plaque near the carotid sinus is a key risk factor for ischemic stroke. Although disturbed hemodynamic environments around atherosclerotic plaque had been investigated in many studies, the effect of their symmetrical features, especially longitudinal asymmetrical characteristics, had not been comparatively studied. In this study, three-dimensional carotid bifurcation models were established based on CT images of three patients with 50% stenosis and with different symmetrical features of carotid atherosclerotic plaques including concentric plaque, eccentric plaque, or eccentric longitudinal asymmetrical plaque. A healthy subject was chosen as the control. Wall shear stress (WSS) and oscillating shear index in the regions of upstream, downstream, downstream shoulders and regions around the point of maximum stenosis were analyzed. The results indicated that the maximum WSS around the eccentric longitudinal asymmetrical plaque were 8.6 times larger than that of the eccentric plaque and 1.9 times larger than that of the concentric plaque. And the distributions of WSS and OSI around the eccentric longitudinal asymmetric plaque were more disordered than those of the others. Our results highlighted the risk of the eccentric longitudinal asymmetrical plaque on plaque development and rupture and might provide a new index for evaluating the development of atherosclerosis.
•We comparatively studied the effect of symmetrical features of atherosclerotic plaque, especially longitudinal asymmetrical characters on hemodynamic environments in this study.•We found the maximum WSS around the eccentric longitudinal asymmetrical plaque were 8.6 times larger than that of the eccentric plaque and 1.9 times larger than that of the concentric plaque.•We found the distributions of WSS and OSI around the eccentric longitudinal asymmetric plaque were more disordered than those of the others, which indicated that the risk of the eccentric longitudinal asymmetrical plaque on plaque development and rupture. |
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| AbstractList | Atherosclerotic plaque near the carotid sinus is a key risk factor for ischemic stroke. Although disturbed hemodynamic environments around atherosclerotic plaque had been investigated in many studies, the effect of their symmetrical features, especially longitudinal asymmetrical characteristics, had not been comparatively studied. In this study, three-dimensional carotid bifurcation models were established based on CT images of three patients with 50% stenosis and with different symmetrical features of carotid atherosclerotic plaques including concentric plaque, eccentric plaque, or eccentric longitudinal asymmetrical plaque. A healthy subject was chosen as the control. Wall shear stress (WSS) and oscillating shear index in the regions of upstream, downstream, downstream shoulders and regions around the point of maximum stenosis were analyzed. The results indicated that the maximum WSS around the eccentric longitudinal asymmetrical plaque were 8.6 times larger than that of the eccentric plaque and 1.9 times larger than that of the concentric plaque. And the distributions of WSS and OSI around the eccentric longitudinal asymmetric plaque were more disordered than those of the others. Our results highlighted the risk of the eccentric longitudinal asymmetrical plaque on plaque development and rupture and might provide a new index for evaluating the development of atherosclerosis.
•We comparatively studied the effect of symmetrical features of atherosclerotic plaque, especially longitudinal asymmetrical characters on hemodynamic environments in this study.•We found the maximum WSS around the eccentric longitudinal asymmetrical plaque were 8.6 times larger than that of the eccentric plaque and 1.9 times larger than that of the concentric plaque.•We found the distributions of WSS and OSI around the eccentric longitudinal asymmetric plaque were more disordered than those of the others, which indicated that the risk of the eccentric longitudinal asymmetrical plaque on plaque development and rupture. Atherosclerotic plaque near the carotid sinus is a key risk factor for ischemic stroke. Although disturbed hemodynamic environments around atherosclerotic plaque had been investigated in many studies, the effect of their symmetrical features, especially longitudinal asymmetrical characteristics, had not been comparatively studied. In this study, three-dimensional carotid bifurcation models were established based on CT images of three patients with 50% stenosis and with different symmetrical features of carotid atherosclerotic plaques including concentric plaque, eccentric plaque, or eccentric longitudinal asymmetrical plaque. A healthy subject was chosen as the control. Wall shear stress (WSS) and oscillating shear index in the regions of upstream, downstream, downstream shoulders and regions around the point of maximum stenosis were analyzed. The results indicated that the maximum WSS around the eccentric longitudinal asymmetrical plaque were 8.6 times larger than that of the eccentric plaque and 1.9 times larger than that of the concentric plaque. And the distributions of WSS and OSI around the eccentric longitudinal asymmetric plaque were more disordered than those of the others. Our results highlighted the risk of the eccentric longitudinal asymmetrical plaque on plaque development and rupture and might provide a new index for evaluating the development of atherosclerosis. |
| ArticleNumber | 100079 |
| Author | Fan, Yubo Zhang, Chi Wang, Yawei Liang, Zhuqing Gong, Xianghui Xie, Sheng |
| Author_xml | – sequence: 1 givenname: Xianghui surname: Gong fullname: Gong, Xianghui organization: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China – sequence: 2 givenname: Zhuqing surname: Liang fullname: Liang, Zhuqing organization: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China – sequence: 3 givenname: Yawei orcidid: 0000-0002-8754-0485 surname: Wang fullname: Wang, Yawei email: wangyawei@buaa.edu.cn organization: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China – sequence: 4 givenname: Chi surname: Zhang fullname: Zhang, Chi organization: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China – sequence: 5 givenname: Sheng surname: Xie fullname: Xie, Sheng organization: Department of Radiology, China-Japan Friendship Hospital, Beijing, China – sequence: 6 givenname: Yubo surname: Fan fullname: Fan, Yubo email: yubofan@buaa.edu.cn organization: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China |
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| Keywords | Symmetrical characteristic Eccentricity index Carotid atherosclerosis Hemodynamic environments |
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