Quercetin and catechin assuage redox imbalance and neurochemical dysfunction in rotenone-induced neurotoxicity: A comparative in vivo experiment supported by in silico study

• Published in: Phytomedicine Plus : International journal of phytotherapy and phytopharmacology Vol. 1; no. 4; p. 100077
• Main Authors: Solomon Josiah, Sunday, Umar, Haruna Isiyaku, Saliu, Ibrahim Olabayode, Akinmoladun, Afolabi Clement
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2021; Elsevier
• Subjects: Catechin; In silico; Neurotoxicity; Quercetin; Rotenone; Structure-function relationships; In silico; Catechin; Neurotoxicity; Quercetin; Rotenone; Structure-function relationships

•Catechin and quercetin lessened cortical and hippocampal redox status imbalance.•They attenuated neurochemical dysfunction in rotenone-induced neurotoxicity.•They interacted effectively against specific targeted enzymes in silico.•Their structural patterns influenced conferred protection against ne...