Quercetin and catechin assuage redox imbalance and neurochemical dysfunction in rotenone-induced neurotoxicity: A comparative in vivo experiment supported by in silico study
•Catechin and quercetin lessened cortical and hippocampal redox status imbalance.•They attenuated neurochemical dysfunction in rotenone-induced neurotoxicity.•They interacted effectively against specific targeted enzymes in silico.•Their structural patterns influenced conferred protection against ne...
Saved in:
Published in | Phytomedicine Plus : International journal of phytotherapy and phytopharmacology Vol. 1; no. 4; p. 100077 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.11.2021
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | •Catechin and quercetin lessened cortical and hippocampal redox status imbalance.•They attenuated neurochemical dysfunction in rotenone-induced neurotoxicity.•They interacted effectively against specific targeted enzymes in silico.•Their structural patterns influenced conferred protection against neurotoxicity.•Quercetin possesses structural advantages to elicit superior activity over catechin.
Quercetin and catechin are structurally-related compounds that are capable of preventing or attenuating oxidative damage and mitochondrial dysfunction. Rotenone is a naturally occurring compound that has been used to model neurotoxicity characterized by Parkinson disease-like symptoms.
This study investigated the comparative property of quercetin and catechin, to ameliorate oxidative damage and neurochemical dysfunction in hippocampal and cortical regions of brain of rats intoxicated with rotenone in vivo, supported by in silico study.
Male Wistar rats were subcutaneously administered rotenone for 10 days followed by post-treatment with catechin or quercetin (5, 10 and 20 mg/kg) for 3 days. Markers of oxidative stress and neurochemical dysfunction were biochemically estimated in the hippocampus and cortex of the brain of rats while in silico study was carried out to evaluate the molecular interaction of some neurochemical enzymes with the compounds.
Quercetin and catechin ameliorated the reduction in complex 1 and Na+K+ATPase activities while attenuating the elevated lactate dehydrogenase activity in the brain of rotenone-intoxicated rats. Disturbances in acetylcholine, dopamine and glutamate metabolism as well as the evoked oxidative stress in rotenone-intoxicated rats were mitigated by quercetin and catechin. The in silico study revealed the key molecular interaction between the flavonoids and targeted enzymes (tyrosine hydroxylase, monoamine oxidase, glutamine synthetase and Na+K+ATPase) to be by hydrogen bond and hydrophobic interaction.
Catechin and quercetin significantly assuaged cortical and hippocampal redox stress and attenuated neurochemical dysfunction caused by rotenone toxicity. Furthermore, this study highlighted that the neuroprotective potentials of the flavonoids is a function of their structural patterns, and quercetin elicited superior activity over catechin due to its structural advantages. |
---|---|
AbstractList | Background: Quercetin and catechin are structurally-related compounds that are capable of preventing or attenuating oxidative damage and mitochondrial dysfunction. Rotenone is a naturally occurring compound that has been used to model neurotoxicity characterized by Parkinson disease-like symptoms. Purpose: This study investigated the comparative property of quercetin and catechin, to ameliorate oxidative damage and neurochemical dysfunction in hippocampal and cortical regions of brain of rats intoxicated with rotenone in vivo, supported by in silico study. Method: Male Wistar rats were subcutaneously administered rotenone for 10 days followed by post-treatment with catechin or quercetin (5, 10 and 20 mg/kg) for 3 days. Markers of oxidative stress and neurochemical dysfunction were biochemically estimated in the hippocampus and cortex of the brain of rats while in silico study was carried out to evaluate the molecular interaction of some neurochemical enzymes with the compounds. Result: Quercetin and catechin ameliorated the reduction in complex 1 and Na+K+ATPase activities while attenuating the elevated lactate dehydrogenase activity in the brain of rotenone-intoxicated rats. Disturbances in acetylcholine, dopamine and glutamate metabolism as well as the evoked oxidative stress in rotenone-intoxicated rats were mitigated by quercetin and catechin. The in silico study revealed the key molecular interaction between the flavonoids and targeted enzymes (tyrosine hydroxylase, monoamine oxidase, glutamine synthetase and Na+K+ATPase) to be by hydrogen bond and hydrophobic interaction. Conclusion: Catechin and quercetin significantly assuaged cortical and hippocampal redox stress and attenuated neurochemical dysfunction caused by rotenone toxicity. Furthermore, this study highlighted that the neuroprotective potentials of the flavonoids is a function of their structural patterns, and quercetin elicited superior activity over catechin due to its structural advantages. •Catechin and quercetin lessened cortical and hippocampal redox status imbalance.•They attenuated neurochemical dysfunction in rotenone-induced neurotoxicity.•They interacted effectively against specific targeted enzymes in silico.•Their structural patterns influenced conferred protection against neurotoxicity.•Quercetin possesses structural advantages to elicit superior activity over catechin. Quercetin and catechin are structurally-related compounds that are capable of preventing or attenuating oxidative damage and mitochondrial dysfunction. Rotenone is a naturally occurring compound that has been used to model neurotoxicity characterized by Parkinson disease-like symptoms. This study investigated the comparative property of quercetin and catechin, to ameliorate oxidative damage and neurochemical dysfunction in hippocampal and cortical regions of brain of rats intoxicated with rotenone in vivo, supported by in silico study. Male Wistar rats were subcutaneously administered rotenone for 10 days followed by post-treatment with catechin or quercetin (5, 10 and 20 mg/kg) for 3 days. Markers of oxidative stress and neurochemical dysfunction were biochemically estimated in the hippocampus and cortex of the brain of rats while in silico study was carried out to evaluate the molecular interaction of some neurochemical enzymes with the compounds. Quercetin and catechin ameliorated the reduction in complex 1 and Na+K+ATPase activities while attenuating the elevated lactate dehydrogenase activity in the brain of rotenone-intoxicated rats. Disturbances in acetylcholine, dopamine and glutamate metabolism as well as the evoked oxidative stress in rotenone-intoxicated rats were mitigated by quercetin and catechin. The in silico study revealed the key molecular interaction between the flavonoids and targeted enzymes (tyrosine hydroxylase, monoamine oxidase, glutamine synthetase and Na+K+ATPase) to be by hydrogen bond and hydrophobic interaction. Catechin and quercetin significantly assuaged cortical and hippocampal redox stress and attenuated neurochemical dysfunction caused by rotenone toxicity. Furthermore, this study highlighted that the neuroprotective potentials of the flavonoids is a function of their structural patterns, and quercetin elicited superior activity over catechin due to its structural advantages. |
ArticleNumber | 100077 |
Author | Solomon Josiah, Sunday Umar, Haruna Isiyaku Akinmoladun, Afolabi Clement Saliu, Ibrahim Olabayode |
Author_xml | – sequence: 1 givenname: Sunday surname: Solomon Josiah fullname: Solomon Josiah, Sunday email: ssjosiah@futa.edu.ng – sequence: 2 givenname: Haruna Isiyaku surname: Umar fullname: Umar, Haruna Isiyaku – sequence: 3 givenname: Ibrahim Olabayode surname: Saliu fullname: Saliu, Ibrahim Olabayode – sequence: 4 givenname: Afolabi Clement surname: Akinmoladun fullname: Akinmoladun, Afolabi Clement |
BookMark | eNp9kc1q3DAUhU1JoWmSN-hCL-CpZMn2OItACP0JBEogWYvrqzsZDR7JSPIwfqi-Y-WZULrqStLV-Y6OOJ-LC-cdFcUXwVeCi-brbjVu53GYVhWvRB5x3rYfisuqadqSSyEv_tl_Km5i3GVJVQspOnVZ_H6eKCAl6xg4wxAS4XY5xDjBG7FAxh-Z3fcwgEM6iRxNweOW9hZhYGaOm8lhst6xDAafaElYWmcmpHd18keLNs237J6h348QINkDLcDBHjyj40jB7sklFqdx9CFlsp-X-2gHi57FNJn5uvi4gSHSzft6Vbx-__by8LN8-vXj8eH-qUQpZVt2IIwQat2RgVZ1TUWyNqrqK2WwM23X87qREuXaVIASZC1AStVsFDe1bGgtr4rHs6_xsNNjTgZh1h6sPg18eNMQksWBdKuoy0wGJVdr1QGg4kqg6XpDqNrspc5eGHyMgTZ__QTXS4M6v3BqUC8N6nODGbs7Y5T_ebAUdERLuQJjA2HKQez_Df4AsA-siQ |
CitedBy_id | crossref_primary_10_3390_molecules27051679 crossref_primary_10_1016_j_phyplu_2021_100112 crossref_primary_10_1016_j_jare_2024_01_030 crossref_primary_10_1111_bcpt_14011 crossref_primary_10_1080_2314808X_2024_2327816 |
Cites_doi | 10.1155/2016/7432797 10.1016/S0736-5748(99)00028-3 10.4103/1673-5374.249847 10.1016/S0021-9258(19)44767-4 10.1007/s12640-016-9600-1 10.1016/j.neuro.2019.03.005 10.2116/analsci.25.1451 10.1523/JNEUROSCI.16-12-03807.1996 10.1016/j.ajpath.2011.04.033 10.1002/ar.23781 10.2174/187152712800792884 10.1186/s41702-020-0057-8 10.1006/abio.1996.0292 10.1002/jcc.21334 10.1016/j.pharep.2018.08.004 10.1038/81834 10.1016/j.jmb.2007.10.029 10.1007/s11064-009-0014-9 10.1016/j.ajps.2017.08.004 10.1016/j.neuint.2018.02.010 10.1016/j.tox.2014.12.005 10.1080/09553009014552121 10.4236/health.2014.610123 10.1191/0960327103ht388oa 10.1021/bi00735a007 10.1016/j.neuroscience.2012.08.060 10.1016/j.fitote.2011.01.018 10.1523/JNEUROSCI.23-34-10756.2003 10.1038/sj.gt.3302520 10.1002/prot.23099 10.1016/0014-5793(75)80385-1 10.1016/j.ejmech.2015.04.040 10.1073/pnas.0710626105 10.1006/bmmb.1994.1004 10.1016/j.pathophys.2018.07.002 10.1038/34923 10.1155/2016/2986796 10.1016/0006-2952(61)90145-9 10.1038/nature07939 10.1016/j.bbabio.2008.11.003 10.1016/0003-2697(76)90527-3 10.1016/j.neuro.2011.08.001 10.1016/S0009-8981(98)00060-6 10.1046/j.1471-4159.2003.01938.x 10.1016/0006-2952(81)90626-2 |
ContentType | Journal Article |
Copyright | 2021 The Author(s) |
Copyright_xml | – notice: 2021 The Author(s) |
DBID | 6I. AAFTH AAYXX CITATION DOA |
DOI | 10.1016/j.phyplu.2021.100077 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef DOAJ Directory of Open Access Journals |
DatabaseTitle | CrossRef |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology |
EISSN | 2667-0313 |
ExternalDocumentID | oai_doaj_org_article_74e936ed53304849aac4041cd9bdec47 10_1016_j_phyplu_2021_100077 S2667031321000592 |
GroupedDBID | 6I. AAEDW AAFTH AAXUO ALMA_UNASSIGNED_HOLDINGS AMRAJ EBS FDB GROUPED_DOAJ M~E OK1 ROL 0R~ 0SF AAHBH AALRI AAYXX ADVLN AFJKZ AITUG AKRWK CITATION |
ID | FETCH-LOGICAL-c3337-9a1d11489eda74962e35d42b24dc9d79b05633c38d2ac3a351a3346f40d536e83 |
IEDL.DBID | DOA |
ISSN | 2667-0313 |
IngestDate | Tue Oct 22 15:01:33 EDT 2024 Thu Sep 26 19:02:49 EDT 2024 Tue Jul 25 20:58:50 EDT 2023 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | In silico Catechin Neurotoxicity Quercetin Rotenone Structure-function relationships |
Language | English |
License | This is an open access article under the CC BY-NC-ND license. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3337-9a1d11489eda74962e35d42b24dc9d79b05633c38d2ac3a351a3346f40d536e83 |
OpenAccessLink | https://doaj.org/article/74e936ed53304849aac4041cd9bdec47 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_74e936ed53304849aac4041cd9bdec47 crossref_primary_10_1016_j_phyplu_2021_100077 elsevier_sciencedirect_doi_10_1016_j_phyplu_2021_100077 |
PublicationCentury | 2000 |
PublicationDate | November 2021 2021-11-00 2021-11-01 |
PublicationDateYYYYMMDD | 2021-11-01 |
PublicationDate_xml | – month: 11 year: 2021 text: November 2021 |
PublicationDecade | 2020 |
PublicationTitle | Phytomedicine Plus : International journal of phytotherapy and phytopharmacology |
PublicationYear | 2021 |
Publisher | Elsevier B.V Elsevier |
Publisher_xml | – name: Elsevier B.V – name: Elsevier |
References | Neidhardt (bib0036) 1996 Pisoschi, Pop (bib0038) 2015; 97 Trott, Olson (bib0047) 2010; 31 Chaudhary, Parvez (bib0012) 2012; 225 Son, Ma, Kondou, Yoshimura, Yamashita, Tsukihara (bib0043) 2008; 105 Haque, Bin-Hafeez, Parvez, Pandey, Sayeed, Ali, Raisuddin (bib0027) 2003; 22 Birch-Machin, Briggs, Saborido, Bindoff, Turnbull (bib0008) 1994; 51 Kakkar, Das, Viswanathan (bib0031) 1984; 21 Craine, Hall, Kaufman (bib0017) 1972; 247 Guevara, Iwanejko, Dembińska-Kieć, Pankiewicz, Wanat, Anna, Gołabek, Bartuś, Malczewska-Malec, Szczudlik (bib0025) 1998; 274 Kumar, Pandey (bib0033) 2013; 162750 Farombi, Awogbindin, Farombi, Oladele, Izomoh, Aladelokun, Ezekiel, Adebambo, Abah (bib0023) 2019; 73 Lee, Lee, Nam, Oh, Cho, Chang (bib0034) 2005; 12 Akinmoladun, Farombi, Farombi (bib0002) 2019; (Vol. 3 Varshney, Kale (bib0049) 1990; 58 Abdel-Zaher, Abdel-Rahman, Elwasei (bib0001) 2011; 32 Guo, Zhang, Li (bib0026) 2009; 25 Chang, Song, Jeon, Yoon, Lee (bib0011) 2011; 179 Betarbet, Sherer, MacKenzie, Garcia-Osuna, Panov, Greenamyre (bib0006) 2000; 3 Krajewski, Collins, Holmberg-Schiavone, Jones, Karlberg, Mowbray (bib0032) 2008; 375 Bradford (bib0010) 1976; 72 Procházková, Boušová, Wilhelmová (bib0039) 2011; 82 Choi, Kim, Xia (bib0013) 2015; 328 Eiserich, Hristova, Cross, Jones, Freeman, Halliwell, van der Vliet (bib0021) 1998; 391 Zaitone, Ahmed, Elsherbiny, Mehanna, El-Kherbetawy, ElSayed, Alshareef, Moustafa (bib0052) 2019; 71 Higgins, Greenamyre (bib0029) 1996; 16 Hussain, Tan, Yin, Blachier, Tossou, Rahu (bib0030) 2016 He, Imam, dong, Jankovic, Ali, Appel, Le (bib0028) 2003; 86 Shinoda, Ogawa, Cornelius, Toyoshima (bib0042) 2009; 459 Crown, Ogundele, Akinmoladun, Famusiwa, Josiah, Olaleye, Akindahunsi (bib0019) 2019; 34 Ullrich, Humpel (bib0048) 2015; 34 Tienhaara, Meany (bib0046) 1973; 12 Cristiana, Elena, Nina (bib0018) 2014; 06 Costa, Garrick, Roquè, Pellacani (bib0016) 2016 Levine, Garland, Oliver, Amici, Climent, Lenz, Ahn, Shaltiel, Stadtman (bib0035) 1990 Stanimirovic, Ball, Small, Muruganandam (bib0044) 1999; 17 Wang, Li, Bi (bib0050) 2018; 13 Ellman, Courtney, Andres, Featherstone (bib0022) 1961; 7 Benzie, Strain (bib0005) 1996; 239 Sharma, Kumar, Deshmukh (bib0040) 2018; 116 Pradja, Weber (bib53) 1975; 59 Clairborne (bib0014) 1985 Bisbal, Sanchez (bib0009) 2019; 14 Parveen, Nawaz, Shakil, Greig, Kamal (bib0037) 2012; 11 Svoboda, Mosinger (bib0045) 1981; 30 Fato, Bergamini, Bortolus, Maniero, Leoni, Ohnishi, Lenaz (bib0024) 2009; 1787 Sherer, Betarbet, Testa, Seo, Richardson, Kim, Miller, Yagi, Matsuno-Yagi, Greenamyre (bib0041) 2003; 23 Stroganov, Novikov, Zeifman, Stroylov, Chilov (bib54) 2011; 79 Wang, Dong, Liu, Zhu, Liu, Fan, Hu, Hu, Yu, Li, Liu, Xie, Gao, Li, Zhang, Ding, Sun (bib0051) 2018; 301 Bae, Kim, Shin, Kim, Kim (bib0004) 2020; 4 Beutler, Duwn, Kelly (bib0007) 1963; 61 Akinmoladun, Oladejo, Josiah, Famusiwa, Ojo, Olaleye (bib0003) 2018; 25 Coasta, Silva, Dos Santos Souza, Santos, Paris, Muňoz, Segura-Aguilar (bib0015) 2016; 30 Costa (10.1016/j.phyplu.2021.100077_bib0016) 2016 Ullrich (10.1016/j.phyplu.2021.100077_bib0048) 2015; 34 Guo (10.1016/j.phyplu.2021.100077_bib0026) 2009; 25 He (10.1016/j.phyplu.2021.100077_bib0028) 2003; 86 Son (10.1016/j.phyplu.2021.100077_bib0043) 2008; 105 Tienhaara (10.1016/j.phyplu.2021.100077_bib0046) 1973; 12 Farombi (10.1016/j.phyplu.2021.100077_bib0023) 2019; 73 Krajewski (10.1016/j.phyplu.2021.100077_bib0032) 2008; 375 Haque (10.1016/j.phyplu.2021.100077_bib0027) 2003; 22 Choi (10.1016/j.phyplu.2021.100077_bib0013) 2015; 328 Abdel-Zaher (10.1016/j.phyplu.2021.100077_bib0001) 2011; 32 Levine (10.1016/j.phyplu.2021.100077_bib0035) 1990 Kumar (10.1016/j.phyplu.2021.100077_bib0033) 2013; 162750 Cristiana (10.1016/j.phyplu.2021.100077_bib0018) 2014; 06 Chang (10.1016/j.phyplu.2021.100077_bib0011) 2011; 179 Fato (10.1016/j.phyplu.2021.100077_bib0024) 2009; 1787 Betarbet (10.1016/j.phyplu.2021.100077_bib0006) 2000; 3 Svoboda (10.1016/j.phyplu.2021.100077_bib0045) 1981; 30 Birch-Machin (10.1016/j.phyplu.2021.100077_bib0008) 1994; 51 Guevara (10.1016/j.phyplu.2021.100077_bib0025) 1998; 274 Akinmoladun (10.1016/j.phyplu.2021.100077_bib0003) 2018; 25 Akinmoladun (10.1016/j.phyplu.2021.100077_bib0002) 2019; (Vol. 3 Stanimirovic (10.1016/j.phyplu.2021.100077_bib0044) 1999; 17 Pradja (10.1016/j.phyplu.2021.100077_bib53) 1975; 59 Trott (10.1016/j.phyplu.2021.100077_bib0047) 2010; 31 Zaitone (10.1016/j.phyplu.2021.100077_bib0052) 2019; 71 Lee (10.1016/j.phyplu.2021.100077_bib0034) 2005; 12 Clairborne (10.1016/j.phyplu.2021.100077_bib0014) 1985 Higgins (10.1016/j.phyplu.2021.100077_bib0029) 1996; 16 Shinoda (10.1016/j.phyplu.2021.100077_bib0042) 2009; 459 Eiserich (10.1016/j.phyplu.2021.100077_bib0021) 1998; 391 Kakkar (10.1016/j.phyplu.2021.100077_bib0031) 1984; 21 Stroganov (10.1016/j.phyplu.2021.100077_bib54) 2011; 79 Beutler (10.1016/j.phyplu.2021.100077_bib0007) 1963; 61 Bae (10.1016/j.phyplu.2021.100077_bib0004) 2020; 4 Parveen (10.1016/j.phyplu.2021.100077_bib0037) 2012; 11 Benzie (10.1016/j.phyplu.2021.100077_bib0005) 1996; 239 Pisoschi (10.1016/j.phyplu.2021.100077_bib0038) 2015; 97 Wang (10.1016/j.phyplu.2021.100077_bib0051) 2018; 301 Sherer (10.1016/j.phyplu.2021.100077_bib0041) 2003; 23 Coasta (10.1016/j.phyplu.2021.100077_bib0015) 2016; 30 Sharma (10.1016/j.phyplu.2021.100077_bib0040) 2018; 116 Bisbal (10.1016/j.phyplu.2021.100077_bib0009) 2019; 14 Neidhardt (10.1016/j.phyplu.2021.100077_bib0036) 1996 Ellman (10.1016/j.phyplu.2021.100077_bib0022) 1961; 7 Bradford (10.1016/j.phyplu.2021.100077_bib0010) 1976; 72 Wang (10.1016/j.phyplu.2021.100077_bib0050) 2018; 13 Chaudhary (10.1016/j.phyplu.2021.100077_bib0012) 2012; 225 Hussain (10.1016/j.phyplu.2021.100077_bib0030) 2016 Varshney (10.1016/j.phyplu.2021.100077_bib0049) 1990; 58 Procházková (10.1016/j.phyplu.2021.100077_bib0039) 2011; 82 Crown (10.1016/j.phyplu.2021.100077_bib0019) 2019; 34 Craine (10.1016/j.phyplu.2021.100077_bib0017) 1972; 247 |
References_xml | – volume: 73 start-page: 132 year: 2019 end-page: 141 ident: bib0023 article-title: Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson's disease publication-title: NeuroToxicol. contributor: fullname: Abah – volume: 14 start-page: 762 year: 2019 end-page: 766 ident: bib0009 article-title: Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach publication-title: Neural Regen. Res. contributor: fullname: Sanchez – volume: 25 start-page: 1451 year: 2009 end-page: 1455 ident: bib0026 article-title: Spectrophotometric determination of dopamine hydrochloride in pharmaceutical, banana, urine and serum samples by potassium ferricyanide-Fe(III) publication-title: Anal. Sci. contributor: fullname: Li – volume: 06 start-page: 975 year: 2014 end-page: 988 ident: bib0018 article-title: Superoxide Dismutase: therapeutic Targets in SOD Related Pathology publication-title: Health contributor: fullname: Nina – volume: 1787 start-page: 384 year: 2009 end-page: 392 ident: bib0024 article-title: Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species publication-title: Biochim. Biophys. Acta contributor: fullname: Lenaz – volume: 179 start-page: 964 year: 2011 end-page: 979 ident: bib0011 article-title: Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells publication-title: Am. J. Pathol. contributor: fullname: Lee – volume: 22 start-page: 473 year: 2003 end-page: 480 ident: bib0027 article-title: Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity publication-title: Hum. Exp. Toxicol. contributor: fullname: Raisuddin – volume: 3 start-page: 1301 year: 2000 end-page: 1306 ident: bib0006 article-title: Chronic systemic pesticide exposure reproduces features of Parkinson's disease publication-title: Nature Neurosci. contributor: fullname: Greenamyre – volume: 225 start-page: 258 year: 2012 end-page: 268 ident: bib0012 article-title: An publication-title: J. Neurosci. contributor: fullname: Parvez – volume: 30 start-page: 427 year: 1981 end-page: 432 ident: bib0045 article-title: Catecholamines and the brain microsomal Na, K-adenosinetriphosphatase-I. Protection against lipoperoxidative damage publication-title: Biochem. Pharmacol. contributor: fullname: Mosinger – volume: 13 start-page: 12 year: 2018 end-page: 23 ident: bib0050 article-title: Bioactive flavonoids in medicinal plants: structure, activity and biological fate publication-title: Asian J. Pharm. Sci. contributor: fullname: Bi – year: 1996 ident: bib0036 article-title: Escherichia coli publication-title: Cell. Mol. Biol. contributor: fullname: Neidhardt – year: 2016 ident: bib0016 article-title: Mechanisms of Neuroprotection by Quercetin: counteracting Oxidative Stress and More publication-title: Oxid. Med. Cell. Longev. contributor: fullname: Pellacani – volume: 51 start-page: 35 year: 1994 end-page: 42 ident: bib0008 article-title: An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria publication-title: Biochem. Med. Metab. Biol. contributor: fullname: Turnbull – volume: 274 start-page: 177 year: 1998 end-page: 188 ident: bib0025 article-title: Determination of nitrite/nitrate in human biological material by the simple Griess reaction publication-title: Clin. Chim. Acta contributor: fullname: Szczudlik – volume: 86 start-page: 1338 year: 2003 end-page: 1345 ident: bib0028 article-title: Role of nitric oxide in rotenone-induced nigro-striatal injury publication-title: J. Neurochem. contributor: fullname: Le – volume: 23 start-page: 10756 year: 2003 end-page: 10764 ident: bib0041 article-title: Mechanism of Toxicity in Rotenone Models of Parkinson's Disease publication-title: J. Neurosci. contributor: fullname: Greenamyre – volume: 162750 year: 2013 ident: bib0033 article-title: Chemistry and biological activities of flavonoids: an overview publication-title: Sci. World J. contributor: fullname: Pandey – volume: 11 start-page: 463 year: 2012 end-page: 468 ident: bib0037 article-title: Molecular Docking Study of Catecholamines and [4-(Propan-2-yl) Phenyl]Carbamic acid with Tyrosine Hydroxylase publication-title: CNS Neurol. Disord. Drug Targets. contributor: fullname: Kamal – volume: 328 start-page: 75 year: 2015 end-page: 81 ident: bib0013 article-title: JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death publication-title: Toxicology contributor: fullname: Xia – volume: 21 start-page: 130 year: 1984 end-page: 132 ident: bib0031 article-title: A modified spectrophotometric assay of superoxide dismutase publication-title: Indian J. Biochem. Biophys. Vol. contributor: fullname: Viswanathan – volume: 34 start-page: 001 year: 2019 end-page: 010 ident: bib0019 article-title: Effects of catechin, quercetin and taxifolin on redox parameters and metabolites linked with renal health in rotenone-toxified rats publication-title: Nig. J. Physiol. Sci. contributor: fullname: Akindahunsi – volume: 79 start-page: 2693 year: 2011 end-page: 2710 ident: bib54 article-title: TSAR, a new graph-theoretical approach to computational modeling of protein side-chain flexibility: modeling of ionization properties of proteins publication-title: Proteins. contributor: fullname: Chilov – volume: 61 start-page: 882 year: 1963 end-page: 888 ident: bib0007 article-title: Improved method for the determination of blood glutathione publication-title: J. Lab. Clin. Med. contributor: fullname: Kelly – volume: 58 start-page: 733 year: 1990 end-page: 743 ident: bib0049 article-title: Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes publication-title: Int. J. Radiat. Biol. contributor: fullname: Kale – volume: 247 start-page: 6082 year: 1972 end-page: 6091 ident: bib0017 article-title: The isolation and characterization of dihydropteridine reductase from sheep liver publication-title: J. Biol. Chem. contributor: fullname: Kaufman – start-page: 464 year: 1990 end-page: 478 ident: bib0035 article-title: Determination of carbonyl content in oxidatively modified proteins publication-title: Methods in Enzymology, Oxygen Radicals in Biological Systems Part B: Oxygen Radicals and Antioxidants contributor: fullname: Stadtman – volume: 12 start-page: 2067 year: 1973 end-page: 2070 ident: bib0046 article-title: The lactate dehydrogenase catalyzed reduction of pyruvate. Active substrate and substrate inhibition publication-title: Biochemistry contributor: fullname: Meany – volume: 59 start-page: 245 year: 1975 end-page: 249 ident: bib53 article-title: Malignant transformation-linked imbalance: Decreased xanthine oxidase activity in hepatomas publication-title: FEBS Letters. contributor: fullname: Weber – volume: 301 start-page: 1115 year: 2018 end-page: 1125 ident: bib0051 article-title: Resveratrol suppresses rotenone-induced neurotoxicity through activation of SIRT1/Akt1 signaling pathway publication-title: Anat. Rec. (Hoboken) contributor: fullname: Sun – volume: 34 start-page: 2147 year: 2015 end-page: 2153 ident: bib0048 article-title: Rotenone induces cell death of cholinergic neuron in an organotypic co-culture brain slice model publication-title: Neurochem. Res. contributor: fullname: Humpel – volume: 31 start-page: 455 year: 2010 end-page: 461 ident: bib0047 article-title: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading publication-title: J. Comput. Chem. contributor: fullname: Olson – volume: 4 start-page: 8 year: 2020 ident: bib0004 article-title: Activity of catechins and their applications publication-title: Biomed. Dermatol. contributor: fullname: Kim – volume: 32 start-page: 725 year: 2011 end-page: 733 ident: bib0001 article-title: Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress publication-title: NeuroToxicology contributor: fullname: Elwasei – volume: 391 start-page: 393 year: 1998 end-page: 397 ident: bib0021 article-title: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils publication-title: Nature contributor: fullname: van der Vliet – volume: 239 start-page: 70 year: 1996 end-page: 76 ident: bib0005 article-title: The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP Assay publication-title: Anal. Biochem. contributor: fullname: Strain – volume: 116 start-page: 104 year: 2018 end-page: 111 ident: bib0040 article-title: Neuroprotective potential of spermidine against rotenone induced Parkinson’s disease in rats publication-title: Neurochem. Int. contributor: fullname: Deshmukh – volume: 82 start-page: 513 year: 2011 end-page: 523 ident: bib0039 article-title: Antioxidant and prooxidant properties of flavonoids publication-title: Fitoterapia contributor: fullname: Wilhelmová – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: bib0010 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal. Biochem. contributor: fullname: Bradford – volume: 71 start-page: 32 year: 2019 end-page: 41 ident: bib0052 article-title: Caffeic acid improves locomotoractivity and lessens inflammatory burden in a mouse model of rotenone-induced nigralneurodegeneration: relevance to Parkinson’s disease therapy publication-title: Pharmacol. Rep. contributor: fullname: Moustafa – volume: 17 start-page: 173 year: 1999 end-page: 184 ident: bib0044 article-title: Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro publication-title: Int. J. Dev. Neurosci. contributor: fullname: Muruganandam – volume: 375 start-page: 217 year: 2008 end-page: 228 ident: bib0032 article-title: Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design publication-title: J. Mol. Biol. contributor: fullname: Mowbray – start-page: 1 year: 2016 end-page: 9 ident: bib0030 article-title: Oxidative Stress and Inflammation: what Polyphenols Can Do for Us? publication-title: Oxid. Med. Cell. Longev. contributor: fullname: Rahu – volume: 16 start-page: 3807 year: 1996 end-page: 3816 ident: bib0029 article-title: [3H] dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study publication-title: J. Neurosci. contributor: fullname: Greenamyre – volume: 105 start-page: 5739 year: 2008 end-page: 5744 ident: bib0043 article-title: Structure of human monoamine oxidase A at 2.2-Å resolution: the control of opening the entry for substrates/inhibitors publication-title: PNAS contributor: fullname: Tsukihara – volume: (Vol. 3, start-page: 370 year: 2019 end-page: 386 ident: bib0002 publication-title: Encyclopedia of Food Chemistry contributor: fullname: Farombi – volume: 30 start-page: 41 year: 2016 end-page: 52 ident: bib0015 article-title: Impact of plant derived flavonoids on neurodegenerative diseases publication-title: Neurotoxicol. Res. contributor: fullname: Segura-Aguilar – volume: 97 start-page: 55 year: 2015 end-page: 74 ident: bib0038 article-title: The role of antioxidants in the chemistry of oxidative stress: a review publication-title: Eur. J. Med. Chem. contributor: fullname: Pop – start-page: 283 year: 1985 end-page: 284 ident: bib0014 article-title: Catalase Activity publication-title: CRC Handbook of Methods for Oxygen Radical Research contributor: fullname: Clairborne – volume: 459 start-page: 446 year: 2009 end-page: 450 ident: bib0042 article-title: Crystal structure of the sodium–potassium pump at 2.4A° resolution publication-title: Nature contributor: fullname: Toyoshima – volume: 12 start-page: 1215 year: 2005 end-page: 1222 ident: bib0034 article-title: Enhanced expression of glutamate decarboxylase 65 improves symptoms of rat parkinsonian models publication-title: Gene Ther. contributor: fullname: Chang – volume: 7 start-page: 88 year: 1961 end-page: 95 ident: bib0022 article-title: A new and rapid colorimetric determination of acetylcholinesterase activity publication-title: Biochem. Pharmacol. contributor: fullname: Featherstone – volume: 25 start-page: 365 year: 2018 end-page: 371 ident: bib0003 article-title: Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: relevance for therapy in pesticide-induced liver toxicity? publication-title: Pathophysiology contributor: fullname: Olaleye – start-page: 1 year: 2016 ident: 10.1016/j.phyplu.2021.100077_bib0030 article-title: Oxidative Stress and Inflammation: what Polyphenols Can Do for Us? publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2016/7432797 contributor: fullname: Hussain – volume: 17 start-page: 173 year: 1999 ident: 10.1016/j.phyplu.2021.100077_bib0044 article-title: Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro publication-title: Int. J. Dev. Neurosci. doi: 10.1016/S0736-5748(99)00028-3 contributor: fullname: Stanimirovic – volume: 14 start-page: 762 issue: 5 year: 2019 ident: 10.1016/j.phyplu.2021.100077_bib0009 article-title: Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach publication-title: Neural Regen. Res. doi: 10.4103/1673-5374.249847 contributor: fullname: Bisbal – volume: 34 start-page: 001 year: 2019 ident: 10.1016/j.phyplu.2021.100077_bib0019 article-title: Effects of catechin, quercetin and taxifolin on redox parameters and metabolites linked with renal health in rotenone-toxified rats publication-title: Nig. J. Physiol. Sci. contributor: fullname: Crown – volume: 247 start-page: 6082 year: 1972 ident: 10.1016/j.phyplu.2021.100077_bib0017 article-title: The isolation and characterization of dihydropteridine reductase from sheep liver publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)44767-4 contributor: fullname: Craine – volume: 30 start-page: 41 issue: 1 year: 2016 ident: 10.1016/j.phyplu.2021.100077_bib0015 article-title: Impact of plant derived flavonoids on neurodegenerative diseases publication-title: Neurotoxicol. Res. doi: 10.1007/s12640-016-9600-1 contributor: fullname: Coasta – volume: 73 start-page: 132 year: 2019 ident: 10.1016/j.phyplu.2021.100077_bib0023 article-title: Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson's disease publication-title: NeuroToxicol. doi: 10.1016/j.neuro.2019.03.005 contributor: fullname: Farombi – volume: 25 start-page: 1451 year: 2009 ident: 10.1016/j.phyplu.2021.100077_bib0026 article-title: Spectrophotometric determination of dopamine hydrochloride in pharmaceutical, banana, urine and serum samples by potassium ferricyanide-Fe(III) publication-title: Anal. Sci. doi: 10.2116/analsci.25.1451 contributor: fullname: Guo – volume: 16 start-page: 3807 year: 1996 ident: 10.1016/j.phyplu.2021.100077_bib0029 article-title: [3H] dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.16-12-03807.1996 contributor: fullname: Higgins – volume: 179 start-page: 964 year: 2011 ident: 10.1016/j.phyplu.2021.100077_bib0011 article-title: Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2011.04.033 contributor: fullname: Chang – volume: 301 start-page: 1115 issue: 6 year: 2018 ident: 10.1016/j.phyplu.2021.100077_bib0051 article-title: Resveratrol suppresses rotenone-induced neurotoxicity through activation of SIRT1/Akt1 signaling pathway publication-title: Anat. Rec. (Hoboken) doi: 10.1002/ar.23781 contributor: fullname: Wang – volume: 61 start-page: 882 year: 1963 ident: 10.1016/j.phyplu.2021.100077_bib0007 article-title: Improved method for the determination of blood glutathione publication-title: J. Lab. Clin. Med. contributor: fullname: Beutler – volume: 162750 year: 2013 ident: 10.1016/j.phyplu.2021.100077_bib0033 article-title: Chemistry and biological activities of flavonoids: an overview publication-title: Sci. World J. contributor: fullname: Kumar – volume: 11 start-page: 463 issue: 4 year: 2012 ident: 10.1016/j.phyplu.2021.100077_bib0037 article-title: Molecular Docking Study of Catecholamines and [4-(Propan-2-yl) Phenyl]Carbamic acid with Tyrosine Hydroxylase publication-title: CNS Neurol. Disord. Drug Targets. doi: 10.2174/187152712800792884 contributor: fullname: Parveen – volume: 4 start-page: 8 issue: 1 year: 2020 ident: 10.1016/j.phyplu.2021.100077_bib0004 article-title: Activity of catechins and their applications publication-title: Biomed. Dermatol. doi: 10.1186/s41702-020-0057-8 contributor: fullname: Bae – volume: 239 start-page: 70 year: 1996 ident: 10.1016/j.phyplu.2021.100077_bib0005 article-title: The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP Assay publication-title: Anal. Biochem. doi: 10.1006/abio.1996.0292 contributor: fullname: Benzie – volume: 31 start-page: 455 year: 2010 ident: 10.1016/j.phyplu.2021.100077_bib0047 article-title: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading publication-title: J. Comput. Chem. doi: 10.1002/jcc.21334 contributor: fullname: Trott – volume: 71 start-page: 32 year: 2019 ident: 10.1016/j.phyplu.2021.100077_bib0052 article-title: Caffeic acid improves locomotoractivity and lessens inflammatory burden in a mouse model of rotenone-induced nigralneurodegeneration: relevance to Parkinson’s disease therapy publication-title: Pharmacol. Rep. doi: 10.1016/j.pharep.2018.08.004 contributor: fullname: Zaitone – volume: (Vol. 3, start-page: 370 year: 2019 ident: 10.1016/j.phyplu.2021.100077_bib0002 contributor: fullname: Akinmoladun – volume: 3 start-page: 1301 year: 2000 ident: 10.1016/j.phyplu.2021.100077_bib0006 article-title: Chronic systemic pesticide exposure reproduces features of Parkinson's disease publication-title: Nature Neurosci. doi: 10.1038/81834 contributor: fullname: Betarbet – volume: 375 start-page: 217 year: 2008 ident: 10.1016/j.phyplu.2021.100077_bib0032 article-title: Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2007.10.029 contributor: fullname: Krajewski – volume: 34 start-page: 2147 issue: 12 year: 2015 ident: 10.1016/j.phyplu.2021.100077_bib0048 article-title: Rotenone induces cell death of cholinergic neuron in an organotypic co-culture brain slice model publication-title: Neurochem. Res. doi: 10.1007/s11064-009-0014-9 contributor: fullname: Ullrich – volume: 13 start-page: 12 issue: 1 year: 2018 ident: 10.1016/j.phyplu.2021.100077_bib0050 article-title: Bioactive flavonoids in medicinal plants: structure, activity and biological fate publication-title: Asian J. Pharm. Sci. doi: 10.1016/j.ajps.2017.08.004 contributor: fullname: Wang – volume: 116 start-page: 104 year: 2018 ident: 10.1016/j.phyplu.2021.100077_bib0040 article-title: Neuroprotective potential of spermidine against rotenone induced Parkinson’s disease in rats publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2018.02.010 contributor: fullname: Sharma – volume: 328 start-page: 75 year: 2015 ident: 10.1016/j.phyplu.2021.100077_bib0013 article-title: JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death publication-title: Toxicology doi: 10.1016/j.tox.2014.12.005 contributor: fullname: Choi – volume: 58 start-page: 733 year: 1990 ident: 10.1016/j.phyplu.2021.100077_bib0049 article-title: Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes publication-title: Int. J. Radiat. Biol. doi: 10.1080/09553009014552121 contributor: fullname: Varshney – volume: 06 start-page: 975 issue: 10 year: 2014 ident: 10.1016/j.phyplu.2021.100077_bib0018 article-title: Superoxide Dismutase: therapeutic Targets in SOD Related Pathology publication-title: Health doi: 10.4236/health.2014.610123 contributor: fullname: Cristiana – volume: 22 start-page: 473 year: 2003 ident: 10.1016/j.phyplu.2021.100077_bib0027 article-title: Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity publication-title: Hum. Exp. Toxicol. doi: 10.1191/0960327103ht388oa contributor: fullname: Haque – volume: 12 start-page: 2067 year: 1973 ident: 10.1016/j.phyplu.2021.100077_bib0046 article-title: The lactate dehydrogenase catalyzed reduction of pyruvate. Active substrate and substrate inhibition publication-title: Biochemistry doi: 10.1021/bi00735a007 contributor: fullname: Tienhaara – year: 1996 ident: 10.1016/j.phyplu.2021.100077_bib0036 article-title: Escherichia coli and Salmonella publication-title: Cell. Mol. Biol. contributor: fullname: Neidhardt – volume: 225 start-page: 258 year: 2012 ident: 10.1016/j.phyplu.2021.100077_bib0012 article-title: An in vitro approach to assess the neurotoxicity of valproic acid-induced oxidative stress in cerebellum and cerebral cortex of young rats publication-title: J. Neurosci. doi: 10.1016/j.neuroscience.2012.08.060 contributor: fullname: Chaudhary – volume: 82 start-page: 513 issue: 4 year: 2011 ident: 10.1016/j.phyplu.2021.100077_bib0039 article-title: Antioxidant and prooxidant properties of flavonoids publication-title: Fitoterapia doi: 10.1016/j.fitote.2011.01.018 contributor: fullname: Procházková – volume: 23 start-page: 10756 issue: 34 year: 2003 ident: 10.1016/j.phyplu.2021.100077_bib0041 article-title: Mechanism of Toxicity in Rotenone Models of Parkinson's Disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-34-10756.2003 contributor: fullname: Sherer – volume: 12 start-page: 1215 year: 2005 ident: 10.1016/j.phyplu.2021.100077_bib0034 article-title: Enhanced expression of glutamate decarboxylase 65 improves symptoms of rat parkinsonian models publication-title: Gene Ther. doi: 10.1038/sj.gt.3302520 contributor: fullname: Lee – volume: 79 start-page: 2693 issue: 9 year: 2011 ident: 10.1016/j.phyplu.2021.100077_bib54 article-title: TSAR, a new graph-theoretical approach to computational modeling of protein side-chain flexibility: modeling of ionization properties of proteins publication-title: Proteins. doi: 10.1002/prot.23099 contributor: fullname: Stroganov – volume: 59 start-page: 245 issue: 2 year: 1975 ident: 10.1016/j.phyplu.2021.100077_bib53 article-title: Malignant transformation-linked imbalance: Decreased xanthine oxidase activity in hepatomas publication-title: FEBS Letters. doi: 10.1016/0014-5793(75)80385-1 contributor: fullname: Pradja – volume: 97 start-page: 55 year: 2015 ident: 10.1016/j.phyplu.2021.100077_bib0038 article-title: The role of antioxidants in the chemistry of oxidative stress: a review publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2015.04.040 contributor: fullname: Pisoschi – volume: 105 start-page: 5739 issue: 15 year: 2008 ident: 10.1016/j.phyplu.2021.100077_bib0043 article-title: Structure of human monoamine oxidase A at 2.2-Å resolution: the control of opening the entry for substrates/inhibitors publication-title: PNAS doi: 10.1073/pnas.0710626105 contributor: fullname: Son – volume: 51 start-page: 35 year: 1994 ident: 10.1016/j.phyplu.2021.100077_bib0008 article-title: An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria publication-title: Biochem. Med. Metab. Biol. doi: 10.1006/bmmb.1994.1004 contributor: fullname: Birch-Machin – start-page: 464 year: 1990 ident: 10.1016/j.phyplu.2021.100077_bib0035 article-title: Determination of carbonyl content in oxidatively modified proteins contributor: fullname: Levine – volume: 25 start-page: 365 issue: 4 year: 2018 ident: 10.1016/j.phyplu.2021.100077_bib0003 article-title: Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: relevance for therapy in pesticide-induced liver toxicity? publication-title: Pathophysiology doi: 10.1016/j.pathophys.2018.07.002 contributor: fullname: Akinmoladun – volume: 391 start-page: 393 year: 1998 ident: 10.1016/j.phyplu.2021.100077_bib0021 article-title: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils publication-title: Nature doi: 10.1038/34923 contributor: fullname: Eiserich – year: 2016 ident: 10.1016/j.phyplu.2021.100077_bib0016 article-title: Mechanisms of Neuroprotection by Quercetin: counteracting Oxidative Stress and More publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2016/2986796 contributor: fullname: Costa – volume: 7 start-page: 88 year: 1961 ident: 10.1016/j.phyplu.2021.100077_bib0022 article-title: A new and rapid colorimetric determination of acetylcholinesterase activity publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(61)90145-9 contributor: fullname: Ellman – volume: 459 start-page: 446 year: 2009 ident: 10.1016/j.phyplu.2021.100077_bib0042 article-title: Crystal structure of the sodium–potassium pump at 2.4A° resolution publication-title: Nature doi: 10.1038/nature07939 contributor: fullname: Shinoda – volume: 1787 start-page: 384 year: 2009 ident: 10.1016/j.phyplu.2021.100077_bib0024 article-title: Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbabio.2008.11.003 contributor: fullname: Fato – volume: 72 start-page: 248 year: 1976 ident: 10.1016/j.phyplu.2021.100077_bib0010 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90527-3 contributor: fullname: Bradford – volume: 21 start-page: 130 issue: 2 year: 1984 ident: 10.1016/j.phyplu.2021.100077_bib0031 article-title: A modified spectrophotometric assay of superoxide dismutase publication-title: Indian J. Biochem. Biophys. Vol. contributor: fullname: Kakkar – volume: 32 start-page: 725 year: 2011 ident: 10.1016/j.phyplu.2021.100077_bib0001 article-title: Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress publication-title: NeuroToxicology doi: 10.1016/j.neuro.2011.08.001 contributor: fullname: Abdel-Zaher – volume: 274 start-page: 177 year: 1998 ident: 10.1016/j.phyplu.2021.100077_bib0025 article-title: Determination of nitrite/nitrate in human biological material by the simple Griess reaction publication-title: Clin. Chim. Acta doi: 10.1016/S0009-8981(98)00060-6 contributor: fullname: Guevara – volume: 86 start-page: 1338 year: 2003 ident: 10.1016/j.phyplu.2021.100077_bib0028 article-title: Role of nitric oxide in rotenone-induced nigro-striatal injury publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2003.01938.x contributor: fullname: He – volume: 30 start-page: 427 year: 1981 ident: 10.1016/j.phyplu.2021.100077_bib0045 article-title: Catecholamines and the brain microsomal Na, K-adenosinetriphosphatase-I. Protection against lipoperoxidative damage publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(81)90626-2 contributor: fullname: Svoboda – start-page: 283 year: 1985 ident: 10.1016/j.phyplu.2021.100077_bib0014 article-title: Catalase Activity contributor: fullname: Clairborne |
SSID | ssj0002513194 |
Score | 2.2247248 |
Snippet | •Catechin and quercetin lessened cortical and hippocampal redox status imbalance.•They attenuated neurochemical dysfunction in rotenone-induced... Background: Quercetin and catechin are structurally-related compounds that are capable of preventing or attenuating oxidative damage and mitochondrial... |
SourceID | doaj crossref elsevier |
SourceType | Open Website Aggregation Database Publisher |
StartPage | 100077 |
SubjectTerms | Catechin In silico Neurotoxicity Quercetin Rotenone Structure-function relationships |
Title | Quercetin and catechin assuage redox imbalance and neurochemical dysfunction in rotenone-induced neurotoxicity: A comparative in vivo experiment supported by in silico study |
URI | https://dx.doi.org/10.1016/j.phyplu.2021.100077 https://doaj.org/article/74e936ed53304849aac4041cd9bdec47 |
Volume | 1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQT7G8NAfUUyOSjBPH3ApqVSEVFamVeovssSMFleyK3a26F_4R_5GZOMsuF7iQQw6JX8k3yYyTbz4r9bbofEG-wYxqcpmuDGW24-cxD6HEugo5kiQ4n3-uz670p-vqem-pL-GEJXngdOPeGR0t1jEIC1I32jpHOtcFBetDJJ3yyItqbzIl72D22mxb8kuZHRD3jAVu8-ZGchdfwuJmzdPDshCeQG7MH35plO_fc097Luf0oXowxYpwnMb4SN2Lw2N1eJHEpjdHcLnLnVoewSFc7GSoN0_Uzy9rIa2s-gHcEECYT8KbBI6W5QMliFLoHfTfvJAbKY6FRnVLmjQEIGyW4vYEOuCKougwzIeY8TSeDWIqvZrf9cSh_Hs4BtpJiUuF2_52DrslBGC5Xowy6gH8Rs4v-xu2QxgVbp-qq9OTy49n2bQ4Q0aIaDLriiBzKRuDM9rWZcQq6NKXOpANxnqOrBAJm1A6QodV4RB13emcoaxjg8_UgYz5uQIRoets1WDead6oyTVVRL7syGiHcaayLTTtImlwtFty2tc2QdkKlG2CcqY-CH6_y4qC9niA7aqd7Kr9l13NlNmi307BSAoyuKn-r92_-B_dv1T3pcmU9fhKHay-r-NrDn9W_s1o6bw__3HyCw3wB50 |
link.rule.ids | 315,786,790,870,2115,27955,27956 |
linkProvider | Directory of Open Access Journals |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quercetin+and+catechin+assuage+redox+imbalance+and+neurochemical+dysfunction+in+rotenone-induced+neurotoxicity%3A+A+comparative+in+vivo+experiment+supported+by+in+silico+study&rft.jtitle=Phytomedicine+Plus+%3A+International+journal+of+phytotherapy+and+phytopharmacology&rft.au=Solomon+Josiah%2C+Sunday&rft.au=Umar%2C+Haruna+Isiyaku&rft.au=Saliu%2C+Ibrahim+Olabayode&rft.au=Akinmoladun%2C+Afolabi+Clement&rft.date=2021-11-01&rft.pub=Elsevier+B.V&rft.issn=2667-0313&rft.eissn=2667-0313&rft.volume=1&rft.issue=4&rft_id=info:doi/10.1016%2Fj.phyplu.2021.100077&rft.externalDocID=S2667031321000592 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2667-0313&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2667-0313&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2667-0313&client=summon |