Expression of HLA-DR genes in gliomas: correlation with clinicopathological features and prognosis

• Published in: Chinese neurosurgical journal Vol. 3; no. 1; pp. 1 - 9
• Main Authors: Fan, Xing, Liang, Jingshan, Wu, Zhifeng, Shan, Xia, Qiao, Hui, Jiang, Tao
• Format: Journal Article
• Language: English
• Published: London BioMed Central 16.08.2017; BMC
• Subjects: Antigens; Brain cancer; Eigenvalues; Gene expression; Genomes; Glioma; Human leukocyte antigen-DR; Immune system; Medical prognosis; Patients; Prognosis; Software; Survival analysis; Tumors; Variance analysis; Beijing China; United States > US; China

Background Human leukocyte antigen (HLA)-DR is a classical major histocompatibility complex (MHC) class II molecule encoded by five genes: HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5. The current study aimed to investigate the role of these genes in gliomas by analyzing microarray data. Metho...