Relationship of HIF‑1α expression with apoptosis and cell cycle in bone marrow mesenchymal stem cells from patients with myelodysplastic syndrome

• Published in: Molecular medicine reports Vol. 26; no. 1
• Main Authors: Qu, Beibei, Han, Xiuhua, Zhao, Lan, Zhang, Feifei, Gao, Qingmei
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.07.2022; D.A. Spandidos
• Subjects: Apoptosis; Apoptosis - genetics; Bone marrow; Cell cycle; Cell Cycle - genetics; Diagnosis; Flow cytometry; Gene expression; Health sciences; Hemopoiesis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1a; Leukemia; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Microenvironments; Mutation; Myelodysplastic syndrome; Myelodysplastic syndromes; Myelodysplastic Syndromes - drug therapy; Osteoprogenitor cells; Progenitor cells; Proteins; Reverse transcription; Risk groups; Stem cells; Therapeutic targets; China; hypoxia‑inducible factor‑1α; bone marrow mesenchymal stem cells; myelodysplastic syndrome

Myelodysplastic syndrome (MDS) is a group of abnormal clonal disorders with ineffective hematopoiesis, which are incurable with conventional therapy. Of note, MDS features an abnormal bone marrow microenvironment, which is related to its incidence. The hypoxia‑inducible factor‑1α (HIF‑1α) transcript...