Coadministration of Voriconazole and Rifabutin Can Increase the Risk of Adverse Drug Reactions in Patients With Multiple Infections

• Published in: Therapeutic drug monitoring Vol. 47; no. 2; p. 303
• Main Authors: Kim, Yoonjin, Bae, Sungyeun, Huh, Ki Young, Joo, Jong Sun, Lee, Jikyo, Song, Sang Hoon, Yu, Kyung-Sang, Jang, In-Jin, Oh, Jaeseong
• Format: Journal Article
• Language: English
• Published: United States 01.04.2025
• Subjects: Adult; Aged; Antifungal Agents - administration & dosage; Antifungal Agents - adverse effects; Drug Interactions - physiology; Drug-Related Side Effects and Adverse Reactions - etiology; Female; Humans; Male; Middle Aged; Retrospective Studies; Rifabutin - administration & dosage; Rifabutin - adverse effects; Rifabutin - therapeutic use; Voriconazole - administration & dosage; Voriconazole - adverse effects; Voriconazole - therapeutic use

Coinfection of tuberculosis or nontuberculous mycobacteria and Aspergillus presents a challenge in medication selection because of the pharmacokinetic interactions between rifampin and voriconazole. Some researchers have suggested the use of rifabutin as an alternative to rifampin because of its low...