The β1 Integrin Activates JNK Independent of CagA, and JNK Activation Is Required for Helicobacter pylori CagA+-induced Motility of Gastric Cancer Cells

• Published in: The Journal of biological chemistry Vol. 283; no. 20; pp. 13952 - 13963
• Main Authors: Snider, Jared L., Allison, Cody, Bellaire, Bryan H., Ferrero, Richard L., Cardelli, James A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.05.2008; American Society for Biochemistry and Molecular Biology

The Helicobacter pylori CagA protein is translocated into gastric epithelial cells through a type IVsecretion system (TFSS), and published studies suggest CagA is critical for H. pylori-associated carcinogenesis. CagA is thought to be necessary and sufficient to induce the motogenic response observe...