Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—includi...

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Published inMedComm - Biomaterials and applications Vol. 4; no. 2
Main Authors Wang, Xin, Chen, Jie, Shi, Hubing
Format Journal Article
LanguageEnglish
Published London John Wiley & Sons, Inc 01.06.2025
Wiley
Subjects
Artificial intelligence
Biocompatibility
Biomarkers
Biomedical materials
Biopsy
Blood platelets
Cancer
circulating tumor cells
Circulatory system
diagnose
Drug delivery systems
Effectiveness
Extracellular vesicles
Medical diagnosis
Metabolism
Metastasis
Mitochondria
Nanomaterials
platelets
platelet‐based nanomaterials
Proteins
Shear stress
Standardization
Tumors
tumor‐educated platelets
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Abstract ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—including mRNA, circular RNA, and long noncoding RNA—offering potential for early cancer detection, prognosis, and treatment monitoring. Additionally, platelet‐derived extracellular vesicles (PEVs) and activation markers (e.g., P‐selectin, CD40L) further enhance their diagnostic utility. However, standardization of platelet biomarker analysis remains a challenge for clinical implementation. Concurrently, nanotechnology is leveraging the natural biocompatibility and targeting properties of platelets to develop platelet‐based drug delivery systems and bioinspired nanomaterials, improving therapeutic precision and efficacy. Moreover, artificial intelligence (AI)‐driven biomarker analysis is refining TEP and PEV profiling, accelerating advances in precision oncology. Future research should focus on establishing standardized protocols, optimizing platelet‐based nanomedicine, and integrating AI to enhance diagnostic accuracy and therapeutic efficacy. By bridging biological insights with clinical applications, platelets hold significant promise as transformative tools in precision oncology. Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and accuracy. Integrating liquid biopsy with nanotechnology offers promising potential in precision oncology.
AbstractList Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—including mRNA, circular RNA, and long noncoding RNA—offering potential for early cancer detection, prognosis, and treatment monitoring. Additionally, platelet‐derived extracellular vesicles (PEVs) and activation markers (e.g., P‐selectin, CD40L) further enhance their diagnostic utility. However, standardization of platelet biomarker analysis remains a challenge for clinical implementation. Concurrently, nanotechnology is leveraging the natural biocompatibility and targeting properties of platelets to develop platelet‐based drug delivery systems and bioinspired nanomaterials, improving therapeutic precision and efficacy. Moreover, artificial intelligence (AI)‐driven biomarker analysis is refining TEP and PEV profiling, accelerating advances in precision oncology. Future research should focus on establishing standardized protocols, optimizing platelet‐based nanomedicine, and integrating AI to enhance diagnostic accuracy and therapeutic efficacy. By bridging biological insights with clinical applications, platelets hold significant promise as transformative tools in precision oncology.
ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—including mRNA, circular RNA, and long noncoding RNA—offering potential for early cancer detection, prognosis, and treatment monitoring. Additionally, platelet‐derived extracellular vesicles (PEVs) and activation markers (e.g., P‐selectin, CD40L) further enhance their diagnostic utility. However, standardization of platelet biomarker analysis remains a challenge for clinical implementation. Concurrently, nanotechnology is leveraging the natural biocompatibility and targeting properties of platelets to develop platelet‐based drug delivery systems and bioinspired nanomaterials, improving therapeutic precision and efficacy. Moreover, artificial intelligence (AI)‐driven biomarker analysis is refining TEP and PEV profiling, accelerating advances in precision oncology. Future research should focus on establishing standardized protocols, optimizing platelet‐based nanomedicine, and integrating AI to enhance diagnostic accuracy and therapeutic efficacy. By bridging biological insights with clinical applications, platelets hold significant promise as transformative tools in precision oncology.
ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine. Tumor‐educated platelets (TEPs) undergo molecular alterations influenced by the tumor microenvironment, with their RNA profiles—including mRNA, circular RNA, and long noncoding RNA—offering potential for early cancer detection, prognosis, and treatment monitoring. Additionally, platelet‐derived extracellular vesicles (PEVs) and activation markers (e.g., P‐selectin, CD40L) further enhance their diagnostic utility. However, standardization of platelet biomarker analysis remains a challenge for clinical implementation. Concurrently, nanotechnology is leveraging the natural biocompatibility and targeting properties of platelets to develop platelet‐based drug delivery systems and bioinspired nanomaterials, improving therapeutic precision and efficacy. Moreover, artificial intelligence (AI)‐driven biomarker analysis is refining TEP and PEV profiling, accelerating advances in precision oncology. Future research should focus on establishing standardized protocols, optimizing platelet‐based nanomedicine, and integrating AI to enhance diagnostic accuracy and therapeutic efficacy. By bridging biological insights with clinical applications, platelets hold significant promise as transformative tools in precision oncology. Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and accuracy. Integrating liquid biopsy with nanotechnology offers promising potential in precision oncology.
Author Shi, Hubing
Chen, Jie
Wang, Xin
Author_xml – sequence: 1
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  orcidid: 0000-0002-1584-3225
  surname: Wang
  fullname: Wang, Xin
  organization: Breast Center, West China Hospital, Sichuan University
– sequence: 2
  givenname: Jie
  surname: Chen
  fullname: Chen, Jie
  email: chenjiewestchina@126.com
  organization: Breast Center, West China Hospital, Sichuan University
– sequence: 3
  givenname: Hubing
  orcidid: 0000-0002-2926-3440
  surname: Shi
  fullname: Shi, Hubing
  email: shihb@scu.edu.cn
  organization: Laboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center
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2017; 9
2021; 39
2023; 132
2011; 20
2019; 116
2024; 552
1999; 94
2021; 40
2019; 112
2017; 403
2015; 14
2015; 16
2008; 19
2014; 111
2019; 145
2004; 10
2021; 13
2015; 28
2012; 90
2021; 12
2021; 11
2015; 29
2019; 134
2011; 186
2014; 344
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Snippet ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in...
Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in nanomedicine....
ABSTRACT Platelets play a pivotal role in cancer detection and metastasis, serving both as novel liquid biopsy biomarkers and as versatile carriers in...
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SubjectTerms Artificial intelligence
Biocompatibility
Biomarkers
Biomedical materials
Biopsy
Blood platelets
Cancer
circulating tumor cells
Circulatory system
diagnose
Drug delivery systems
Effectiveness
Extracellular vesicles
Medical diagnosis
Metabolism
Metastasis
Mitochondria
Nanomaterials
platelets
platelet‐based nanomaterials
Proteins
Shear stress
Standardization
Tumors
tumor‐educated platelets
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Title Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery
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